| Livin与消化道肿瘤 |
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| 引用本文： | 鲍官明.Livin与消化道肿瘤[J].世界肿瘤杂志,2009,8(3):197-200. |
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| 作者姓名： | 鲍官明 |
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| 作者单位： | 皖南医学院弋矶山医院肿瘤中心,安徽芜湖241000 |
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| 摘 要： | 凋亡蛋白抑制因子（inhibitor of apoptosis protein，IAP）是一类抑制凋亡的调节分子，其成员Livin是新发现的凋亡抑制基因，通过与内源IAP抑制剂SMAC和Caspase－3，Caspase－7，Caspase－9结合，发挥抗细胞凋亡的作用。与多种肿瘤的发生密切相关。我们就其分子结构、生物学特征、抗细胞凋亡作用机制以及与消化系统肿瘤的关系等研究现状作一介绍。
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| 关 键 词： | Livin 细胞调亡 消化系统肿瘤 |
Study of Livin and digestive system cancer |
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| Institution: | BAO Guan-ming, WANG Yin-ke, WANG Lu (Cancer center, Yijishan hospital of Wannan Medical College, Wuhu Anhui 241000, China) |
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| Abstract: | Inhibitor of apoptosis proteins （inhibitor of apoptosis protein, lAP） are a class of molecules which inhibit apoptosis. Livin, as a newly discovered member of IAPs, inhibit apoptosis through combining with endogenous SMAC and Caspase-3, Caspase-7, Caspase-9, and is closely related to the occurrence of a wide variety of tumors. We mainly introduce the research status of molecular structure, biological characteristics, anti-apoptosis mechanisms and the relationship with the digestive system tumors. |
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| Keywords: | Livin apoptosis digestive system Cancer |
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