生栀子、焦栀子50%和95%乙醇洗脱部位药效学比较研究

目的:对炮制前后变化明显的组分50%和95%乙醇洗脱部位(简称部位)进行药效学比较研究,为阐明栀子的炮制原理和栀子饮片的合理应用提供科学依据。方法:采用抗炎、镇静、凝血及化学性肝损伤等指标,观察生栀子、焦栀子50%和95%部位作用的差别。结果:生栀子、焦栀子50%和95%部位对小鼠炎症反应有较好的抑制作用,对小鼠镇静作用不明显,对四氯化碳造成的肝损伤没有保护作用,焦栀子95%部位有明显的促进血液凝固的作用。结论:生栀子、焦栀子两个洗脱部位抗炎作用较好,对镇静和肝损伤作用不明显。焦栀子95%部位凝血作用明显,有较好的止血功效。

Pharmacological Study on Elution Parts of Fructus Gardeniae Ellis and Stirbaked Fructus Gardeniae Praeparatus by 50% or 95% Alcohol Separately

Objective:In order to provide the scientific evidence for clinical use of Fructus Gardeniae with different processing form,the comparative pharmacodynamical study was carried out on elution Parts of Fructus Gardeniae and Fructus Gardeniae Praeparatus eluted by 50% or 95% alcohol separately.Methods:To observe the influence of elution parts of Fructus Gardeniae and Fructus Gardeniae Praeparatus eluted by 50% or 95% alcohol on inflammatory,sedative,blood coagulation,and hepatic injury induced by CCl_4.Results:The experimental eluted parts have shown significant effects of anti-inflammatory,while neither of them has shown sedative effects or protective effect against hepatic injury induced by CCl_4.In addition,the elution part of Fructus Gardeniae Praeparatus eluted by 95% alcohol,has effect of promoting blood coagulation.Conclusion:The experimental elution parts of Fructus Gardenia and Stir-baked Fructus Gardeniae Praeparatus have show obvious effects of anti-inflammatory.Eluted part of Stir-baked Fructus Gardeniae Praeparatus by 95% alcohol has shown better effect of promoting blood coagulation.None of the eluted parts showed obvious sedative or hepatic protective effects.