| 抗氧化剂防治抗癫痫药所致周围神经损伤的实验性研究 |
| |
| 引用本文： | 钟敏,蔡方成,张晓萍,宋艳.抗氧化剂防治抗癫痫药所致周围神经损伤的实验性研究[J].第三军医大学学报,2008,30(23):2219-2222. |
| |
| 作者姓名： | 钟敏 蔡方成 张晓萍 宋艳 |
| |
| 作者单位： | 重庆医科大学附属儿童医院神经内科,重庆,400014;重庆医科大学附属儿童医院神经内科,重庆,400014;重庆医科大学附属儿童医院神经内科,重庆,400014;重庆医科大学附属儿童医院神经内科,重庆,400014 |
| |
| 摘 要： | 目的探讨抗氧化剂维生素E和银杏叶提取物（Ginkgo biloba extract,GBE）对抗癫痫药物致周围神经损伤的防治功效。方法不同年龄大鼠（7d和2个月）随机分组后分别灌喂抗癫痫药物及抗氧化剂,并取坐骨神经用于组织病理观察,同时检测坐骨神经组织匀浆和大鼠血清抗氧化指标。结果补充抗氧化剂后,两年龄组原纤维病变率均显著下降（P〈0.01）,血清和周围神经组织抗氧化能力显著改善（P〈0.05,P〈0.01）。结论GBE和维生素E通过改善体内超氧化-抗氧化平衡,可有效防治抗癫痫药物导致的周围神经损伤。
|
| 关 键 词： | 抗癫痫药 周围神经 抗氧化剂 氧化应激 |
Antioxidants protects against peripheral nerve damages induced by antiepileptic drugs in rats |
| |
| ZHONG Min,CAI Fang-cheng,ZHANG Xiao-ping,SONG Yan.Antioxidants protects against peripheral nerve damages induced by antiepileptic drugs in rats[J].Acta Academiae Medicinae Militaris Tertiae,2008,30(23):2219-2222. |
| |
| Authors: | ZHONG Min CAI Fang-cheng ZHANG Xiao-ping SONG Yan |
| |
| Abstract: | Objective To explore the protective efficacy of antioxidants (vitamin E and Ginkgo biloba extract) on the peripheral nerve damages induced by antiepileptic drugs (AEDs). Methods Adult (2-month old) and infant SD rats (7-day old) were respectively treated with AEDs (phenytoin,or phenobarbital,or clonazepam) alone,or simultaneously with vitamin E or Ginkgo biloba extract for 4 weeks. All the rats were sacrificed,sciatic nerves and serum were collected. The sciatic nerves were analyzed by histologically for th... |
| |
| Keywords: | antiepileptic drugs peripheral nerves antioxidants oxidative stress |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
