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| 红色糖多孢菌变温发酵生产红霉素的研究 | |
| 引用本文： | 宋小锋,许平辉,周桂香,原增艳,王玉玺,吴坤. 红色糖多孢菌变温发酵生产红霉素的研究[J]. 中国抗生素杂志, 2009, 34(12): 722. DOI: 1001-8689 (2009) 12-0722-04 |
| 作者姓名： | 宋小锋 许平辉 周桂香 原增艳 王玉玺 吴坤 |
| 作者单位： | 1. 河南农业大学生命科学学院,郑州,450002 2. 郑州市医药科技开发中心,郑州,45000 3. 河南天方药业股份有限公司,驻马店,463000 |
| 摘 要： | 考察了不同温度(29~34℃)对红色糖多孢菌(Saccharopolyspora |
| 关 键 词： | 红色糖多孢菌 红霉素 变温发酵 |
| 收稿时间： | 2009-04-03 |
Studies of temperature shift fermentation for erythromycin production by Saccharopolyspora erythraea HA |
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| Song Xiao-feng,Xu Ping-hui,Zhou Gui-xiang,Yuan Zeng-yan,Wang Yu-xi,Wu Kun. Studies of temperature shift fermentation for erythromycin production by Saccharopolyspora erythraea HA[J]. Chinese Journal of Antibiotics, 2009, 34(12): 722. DOI: 1001-8689 (2009) 12-0722-04 | |
| Authors: | Song Xiao-feng Xu Ping-hui Zhou Gui-xiang Yuan Zeng-yan Wang Yu-xi Wu Kun |
| Affiliation: | 1 College of Life Science; Henan Agricultural University; Zhengzhou 450002; 2 The Medical Sci-tech Development Center of Zhengzhou; Zhengzhou 450000; 3 Henan Topfond Pharmaceutical Co.LTD; Zhumadian 463000 |
| Abstract: | Fermentation for Erythromycin production by Saccharopolyspora erythraea HA at various temperature between 29℃and 34℃was investigated and the dynamics characteristics during fermentation process were also analyzed.Based on the results,a varying temperature nursing method of three stage control strategy is proposed:During the first stage,which comprises the lag phase and the index phase,the temperature is maintained at 33℃;then the temperature is shifted to 32℃in the ferment middle phase and dropped to 29℃ at the end of the fermentation process.By this method.the erythromycin titres of biological and aye chemical assays 1 1.1%and 24%higher than that of fixed temperature(32℃)fermentation. |
| Keywords: | Saccharopolyspora erythraea Erythromycin Temperature shift fermentation |
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