清热痤疮片治疗女性迟发性寻常痤疮临床观察

目的：观察清热痤疮片治疗女性迟发性(≥25岁)寻常痤疮的临床疗效及其对性激素的影响。方法：选取女性迟发性寻常痤疮共60例，随机分为治疗组(40例)和对照组(20例)，分别采用中药清热痤疮片和安体舒通、四环素、甲硝唑三联疗法，并选取≥25岁健康女性10例为健康人组，观察治疗组和对照组及健康人组血清睾酮(T)、雌二醇(E2)水平，治疗组和对照组临床疗效、治疗前后T、E2水平比较。结果：治疗前治疗组及对照组血清T水平均高于健康人组(P<0．01)；治疗组和对照组总有效率分别为92．5％、90．0％，两组比较差异无显著性(P>0．05)；治疗后治疗组血清T水平明显下降(P<0．01)，E2水平变化不明显；对照组治疗后血清T、E，水平变化不明显(P>0．05)。结论：中药清热痤疮片治疗女性迟发性寻常痤疮临床疗效确切，可降低血清T水平，药物不良反应少。

Clinical Observation on Treatment of Female Delayed Acne Vulgaris with Qingre Cuochuang Tablet

OBJECTIVE: To observe the clinical therapeutic effect of Qingre Cuochuang tablet (QCT) in treating female delayed acne vulgaris (FDAV, with patients age more than 25 years old), to evaluate objectively the sexual hormone in patients and to assess the effect of QCT on sexual hormone. METHODS: Sixty FDAV patients were randomly divided into the treated group (n = 40) and the control group (n = 20), they were treated with QCT and western medicine (including antisterone, tetracycline and metronidazole) respectively. Besides, 10 healthy female subjects aged > or = 25 years were selected as normal control. Serum levels of testosterone (T) and estradiol (E2) in all patients and healthy subjects as well as the clinical therapeutic effect of the treatments were observed and compared. RESULTS: The total effective rate in the treated group and the control group was 92.5% and 90.0% respectively, comparison between them showed insignificant difference. Serum level of T in the patients before treatment were higher than that in healthy subjects (P < 0.01), and showed no difference between the treated group and the control group. After treatment, it lowered significantly in the treated group (P < 0.01), but unchanged in the control group, E2 level showed no significant change in both groups before and after treatment. CONCLUSION: QCT has definite clinical effect in treating FDAV, it could lower the serum level of T and with few adverse reaction.