兴奋红核引起的心血管反应与脑内某些递质系统关系的探讨

本实验选用 14只Wistar大鼠,采用侧脑室注射和电刺激红核(RN)的方法,对兴奋RN引起的心血管反应的脑内途径做了初步探讨。结果表明,脑室内注射多巴胺(DA)可使兴奋RN引起的升压效应增强(P<0.01)、心率(HR)增快(P<0.01);注射去甲肾上腺素(NA)则使兴奋RN引起的升压效应减弱(P<0.01)、HR减慢(P<0.01);α受体阻断剂酚妥拉明(Phen)能有效地拮抗NA对RN的抑制效应(P<0.01)。说明RN在调控心血管活动过程中,即可通过DA系统得到加强,又可使NA系统受到制约,DA和NA两个递质系统都是RN调控心血管活动的脑内途径。

Research on relationship between cardiovascular response to excitation of red nucleus and some transmitter systems in the brain

In our other studies, it was proved that the excited red nucleus (RN) showed effects of an increase of the blood pressure (BP) and acceleration of the heart rate (HR). In order to find out the pathways of the regulatory effect of RN on the cardiovascular activition, the experiments were done using the method of injection of drugs into the cerebroventricle (icv).We found that icv dopamine (DA) could strengthen the effects of electrical stimulation of RN on BP and HR (P<0. 01), Noradrenaline (NA) could weaken it, and the α - blocker phentolamine (Phen) could antagonize powerfully the effect of NA (P<0. 01). These results showed that it is posi-ble for the DA and NA systems to be two pathways of the regulatory effect of RN on the cardiovascular activition.