慢性丙型肝炎患者2型糖尿病并发率调查及其基因型特征分析

目的通过调查慢性丙型肝炎患者2型糖尿病并发率及其与所感染丙型肝炎病毒（HCV）基因型的关系。进一步探讨糖尿病是否为丙型肝炎的肝外表现之一。方法采用荧光定量聚合酶链反应和聚合酶链反应一微板核酸杂交酶联免疫技术对308例慢性丙型肝炎、305例慢性乙型肝炎患者进行乙型肝炎病毒、HCV定性．定量检测和HCV基因型分析并比较其与对照人群糖尿病并发率的差异。结果慢性丙型肝炎患者糖尿病并发率为32．79％，明显高于慢性乙型肝炎（9．84％）及对照组（8．39％）。合并糖尿病的慢性丙型肝炎患者血清丙氨酸氨基转移酶及总胆红素水平显著高于未合并糖尿病者，且以1b型HCV的感染率为最高，占40．59％，与未合并糖尿病者相比差异有统计学意义。结论慢性丙型肝炎患者糖尿病并发率高，以1b型多见，且病情相对较重。

Investigation on the incidence of diabetes in chronic hepatitis C patients and their HCV genotypes

Objectives To investigate the incidence of type 2 diabetes mellitus in patients with chronic hepatitis C (CHC) and its relation to HCV genotypes, and to confirm whether diabetes is an exohepatic manifestation of CHC. Methods Sandwich hybridization microplate assays and fluorescence quantification PCR technology were used to detect HBV DNA, HCV RNA and HCV genotypesof 308 chronic hepatitis C patients and 305 chronic hepatitis B patients. The incidence of diabetes in these patients was compared and analyzed with that in 310 controls. Results The incidence of diabetes in patients with chronic hepatitis C was 32.79%, higher than that in patients with chronic hepatitis B (9.84%) and in the control group (8.39%). Serum levels of ALT and TBIL in hepatitis C patients with diabetes were higher than those without diabetes. Infection rate of HCV lb in hepatitis C patients with diabetes was the highest (40.59%), and when compared with that of those without diabetes the difference was very significant. Conclusion Incidence of diabetes mellitus in patients with chronic hepatitis C is high, especially those infected with HCV lb, and the liver functions of these patients are more severely damaged.