| rhIL—11对^60Coγ射线照射猕猴造血功能恢复的影响 |
| |
| 引用本文： | 郝静 罗庆良 熊国林 柳晓兰 邱丽玲 陈国志 李元敏 陈望秋 沈纯. rhIL—11对^60Coγ射线照射猕猴造血功能恢复的影响[J]. 中华肿瘤杂志, 2001, 23(1): 21-24 |
| |
| 作者姓名： | 郝静 罗庆良 熊国林 柳晓兰 邱丽玲 陈国志 李元敏 陈望秋 沈纯 |
| |
| 作者单位： | 郝静（100850北京放射医学研究所一室）;罗庆良（100850 北京放射医学研究所一室）;熊国林（100850 北京放射医学研究所一室）;柳晓兰（100850 北京放射医学研究所一室）;邱丽玲（100850 北京放射医学研究所一室）;陈国志（100850 北京放射医学研究所一室）;李元敏（100850 北京放射医学研究所一室）;陈望秋（医进生物技术北京有限公司）;沈纯（医进生物技术北京有限公司） |
| |
| 摘 要： | 目的观察重组人白介素-11(recombinanthumaninterleukin-11,rhIL-11)对亚致死剂量γ射线照射所致急性放射病猕猴血细胞减少的治疗作用。方法19只正常成年猕猴用
|
| 关 键 词： | 急性放射损伤 白细胞介素11 造血功能恢复 rhIL－11 |
| 修稿时间： | 1999-12-02 |
The effect of rhIL-11 on hematopoiesis of rhesus monkeys irradiated with 60Co gamma-rays] |
| |
| HAO Jing,. The effect of rhIL-11 on hematopoiesis of rhesus monkeys irradiated with 60Co gamma-rays][J]. Chinese Journal of Oncology, 2001, 23(1): 21-24 |
| |
| Authors: | HAO Jing |
| |
| Affiliation: | Beijing Institute of Radiation Medicine, Beijing 100850, China. |
| |
| Abstract: | OBJECTIVE: To study the therapeutic effect of recombinant human interleukin-11 (rhIL-11) on acute radiation sickness in monkeys. METHODS: rhIL-11 (30, 60, 120 micrograms.kg-1.d-1, s.c., on days 0-13 after TBI) or vehicle was administered to rhesus monkeys irradiated with 3.0 Gy 60Co gamma-rays. RESULTS: The nadirs of platelet count were significantly improved after treatment with rhIL-11. The duration of platelet and leukocyte numbers below 50% of their baseline values was shortened. Erythrocyte recovery was also accelerated. Semi-solid bone marrow cell culture demonstrated that rhIL-11 could stimulate monkey's bone marrow cell to form more CFU-MK, CFU-Mix, CFU-E and BFU-E in vitro, especially at the dose of 60 micrograms.kg-1.d-1. Histopathological observation revealed that bone marrow of the untreated controls showed large area of bleeding whereas that of the rhIL-11 treated monkeys was in active proliferation. CONCLUSION: rhIL-11 can accelerate hematopoietic recovery of monkeys received 3.0 Gy total body gamma-rays irradiation. |
| |
| Keywords: | |
|
