氨磺必利与齐拉西酮对精神分裂症的随机、开放性对照研究 |
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引用本文: | 邓良华,刘青梅,唐立岩,许世欢,徐健.氨磺必利与齐拉西酮对精神分裂症的随机、开放性对照研究[J].中国民政医学杂志,2013(17):7-9. |
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作者姓名: | 邓良华 刘青梅 唐立岩 许世欢 徐健 |
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作者单位: | 广东省佛山市顺德伍仲佩纪念医院,广东佛山528300 |
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摘 要: | 目的:比较氨磺必利与齐拉西酮在治疗精神分裂症的疗效和不良反应。方法:将78例符合标准的成年精神分裂症患者随机分为两组,氨磺必利组(n=38)口服氨磺必利治疗;齐拉西酮组(n=40)口服齐拉西酮治疗。观察8周。于治疗前以及治疗后第2周、第4周、第8周末,用PANSS量表评定临床效果,用不良反应量表(TESS)评定不良反应。结果:治疗结束时,两组PANSS评分较入组时均有显著降低(P〈0.05),两组组间比较,无明显差异(P〉0.05),两者不良反应较少两组间比较无明显差异(P〉0.05)。结论:氨磺必利与齐拉西酮对精神分裂症的治疗安全有效,氨磺必利对情感症状较齐拉西酮有更好的治疗效果。
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关 键 词: | 氨磺必利 齐拉西酮 精神分裂症 疗效 |
Randomized and open control study for amisulpride and ziprasidone in treatment of schizophrenia |
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Institution: | DENG Hang- hua, LIU Qing- mei, TANG Li -yan, et al (Wuzhongpei Memorial Hospital in Shunde District of Foshan City, Guangdong 528300, China) |
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Abstract: | Objective: To compare efficacy and adverse reactions of amisulpride and ziprasidone in treatment of schizophrenia.Methods: 78 adult cases of schizophrenia meeting the diagnostic criteria were randomly assigned to amisulpride group(n = 38)(orally taking amisulpride for 8 weeks) and ziprasidone group(n = 40)(orally taking ziprasidone for 8 weeks).The efficacy and adverse reactions were evaluated with PANSS and TESS before and 2,4,and 8 weeks after the treatment.Results: After the treatment,the scores of PANSS in both groups decreased significantly compared with the baseline(P 0.05).Both group had fewer adverse reactions.Conclusions: Amisulpride and ziprasidone are safe and effective in the treatment of schizophrenia,however,amisulpride is better than ziprasidone for treating depress symptoms. |
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Keywords: | Amisulpride Ziprasidone Schizophrenia Therapeutic efficacy |
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