帕利哌酮与喹硫平治疗老年患者脑血管病所致精神病性障碍的对照研究

目的：比较帕利派酮与喹硫平治疗老年患者脑血管病所致精神病性障碍的疗效及安全性。方法：对38例老年患者脑血管病所致精神病性障碍患者随机分为帕利哌酮和喹硫平两组,治疗4周。治疗前后采用简明精神病量表（BPRS）及不良反应量表（TESS）评定疗效和不良反应。结果：治疗4周后两组BPRS评分均有显著性下降（P〈0.05或者P〈0.01）。帕利哌酮组治疗有效率94.44%,喹硫平组治疗有效率83.33%,两组比较有统计学意义（P〈0.05）,两组TESS评分以帕利哌酮组的不良反应较喹硫平组轻（P〈0.01）。结论：帕利哌酮在治疗老年患者脑血管病所致精神病性障碍疗效确切,不良反应较喹硫平少。帕利哌酮更适用于老年患者脑血管病所致精神病性障碍的治疗。

Control study for paliperidone and quetiapine in treatment of elderly patients with psychotic disorders caused by cerebrovascular diseases

Objective： To investigate efficacy and safety of paliperidone and quetiapine in treatment of elderly patients with psychotic disorders caused by cerebrovascular diseases.Methods： 38 elderly patients with psychotic disorders caused by cerebrovascular diseases were randomly divided into paliperidone group quetiapine group,and treated for 4 weeks.The efficacy was measured by Brief Psychiatric Rating Scale（BPRS）,and side effects were evaluated by Treatment Emergent Symptom Scale（TESS） before and after the treatment.Results： After the treatment,the BPRS scores were improved significantly for both groups（P 0.05 or P 0.01）.The effective rate of paliperidone group was 94.44%,whereas that of quetiapine group was 83.33%,and there was a statistical significance between the two groups（P 0.05）.The TESS scores of Paliperidone group were significantly lower than those of quetiapine group（P 0.01）.Conclusions： Paliperidone is effective in the treatment of the elderly patients with psychotic disorders caused by cerebrovascular diseases,and has less side effects compared with quetiapine.Moreover,Paliperidone is superior in the efficiency.