| 纳米级支架材料在骨组织工程中的应用 |
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| 引用本文： | 赵君,蒋欣泉,张志愿. 纳米级支架材料在骨组织工程中的应用[J]. 中国口腔颌面外科杂志, 2008, 6(2): 137-140 |
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| 作者姓名： | 赵君 蒋欣泉 张志愿 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院·口腔医学院,口腔颌面外科,上海市口腔医学研究所,上海市口腔医学重点实验室,上海,200011 |
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| 基金项目： | 国家自然科学基金 , 上海市科委资助项目 , 上海市重点学科建设项目 |
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| 摘 要： | 骨组织工程研究领域中，支架材料与细胞的相互作用是主要的研究课题。支架材料表面的微观结构对细胞的生物调控作用非常重要。纳米材料因具有一些独特的效应，有利于细胞的黏附、增殖和功能的增强，因而作为骨组织工程支架有着良好的应用前景。目前用于骨组织工程的纳米支架材料主要有纳米复合材料和纳米纤维材料。作者就纳米支架材料与细胞作用的机制以及近年来其在骨组织工程中的应用研究现状作一综述。
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| 关 键 词： | 纳米材料 支架材料 骨组织工程 |
| 文章编号： | 1672-3244(2008)02-0137-04 |
| 修稿时间： | 2007-04-09 |
The application of nanostructured scaffold materials in bone tissue engineering |
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| ZHAO Jun,JIANG Xin-quan,ZHANG Zhi-yuan. The application of nanostructured scaffold materials in bone tissue engineering[J]. China Journal of Oral and Maxillofacial Surgery, 2008, 6(2): 137-140 |
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| Authors: | ZHAO Jun JIANG Xin-quan ZHANG Zhi-yuan |
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| Affiliation: | .(Department of Oral and Maxillofacial Surgery, College of Stomatology, Ninth People＇s Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Research Institute of Stomatology, Shanghai Key Laboratory of Stomatology. Shanghai 200011, China) |
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| Abstract: | The study of scaffold material-cell interactions was the major subject in the field of bone tissue engineering. Micro-structured surfaces of materials had more remarkably biological control on cells. Nanostructured scaffold materials have particular effects which could enhance biologic activity,adhesiveness and proliferation of cells. At present, nanocomposite constructs and nanofiber scaffolds are the major materials researched in bone tissue engineering. This review focuses on the mechanism of nanomaterial-cell interactions and the present status of application of nanomaterials in bone tissue engineering. Supported by National Natural Science Foundation of China（Grant No.30400502）, Research Fund of Science and Technology Committee of Shanghai Municipality （Grant No.04dz05601,05DJ14006, 055407034, 05QMX1426） and Shanghai Leading Academic Discipline Project（Grant No.Y0203）. |
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| Keywords: | Nanomaterials Scaffold Bone tissue engineering |
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