Prevalence and genetic relatedness of methicillin-susceptible Staphylococcus aureus isolates detected by the Xpert MRSA nasal assay |
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| Authors: | Arbefeville Sophie S Zhang Kunyan Kroeger Jennifer S Howard Wanita J Diekema Daniel J Richter Sandra S |
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| Affiliation: | Department of Clinical Pathology, Cleveland Clinic, 9500 Euclid Avenue, L40, Cleveland, OH 44195, USA. |
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| Abstract: | Methicillin-susceptible Staphylococcus aureus (MSSA) isolates lacking mecA yet testing positive on the Xpert MRSA assay were recovered from culture for 7.7% of 248 Xpert-positive nasal samples. These "false-positive" Xpert results may be attributed to staphylococcal cassette chromosome (SCC) elements without the mecA gene. Pulsed-field gel electrophoresis (PFGE) analysis revealed a diverse population of MSSA strains. |
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