| 阿霉素脂质体的冻干工艺考察 |
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| 引用本文： | 贾莉,赵辉,刘沛沛.阿霉素脂质体的冻干工艺考察[J].北方药学,2013,0(8):63-64. |
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| 作者姓名： | 贾莉 赵辉 刘沛沛 |
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| 作者单位： | 山东省菏泽医学专科学校 菏泽 274000;山东省泰安市中医院药剂科 泰安 271000 |
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| 摘 要： | 目的:对阿霉素脂质体冻干工艺进行考察。方法:以外观、再分散性、粒径为指标,对冻干工艺中参数进行优化。结果:优化的冻干工艺为-75℃预冻24h,升温至-25℃保持16h,再升温至20℃持续8h,选择10%海藻糖作为阿霉素脂质体的冻干保护剂。结论:通过优化冻干工艺参数,所得的阿霉素脂质体冻干制品外观平整、质地疏松,加水后能迅速分散均匀。
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| 关 键 词： | 阿霉素脂质体 冻干工艺 |
Optimization of the preparation of the freez-drying Doxorubicin-Liposomes |
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| Jia Li
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Zhao Hui
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Liu Peipei.Optimization of the preparation of the freez-drying Doxorubicin-Liposomes[J].BEIFANG YAOXUE,2013,0(8):63-64. |
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| Authors: | Jia Li Zhao Hui Liu Peipei |
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| Institution: | Jia Li Zhao Hui Liu Peipei (1.Heze Medical Colleges,Heze,Shandong 27400,China;2.Tai＇an Hospital of Traditional Chinese Medicine,Tai＇an,Shandong 271000,China) |
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| Abstract: | Objietive：To optimize the preparation and formulation of the freez-drying Liposomes.Methods：The physicochemical properties of liposome before and after freez-drying were studied,such as particle shape,appearance and particle diameter.Results：Processing factors were optimized base on the optimized preparation and formulation：frozen time 24h,heating-up to-25℃ 16h,then heating-up to 20℃ 8h.Trehalose was ensure to protect liposome as cryoprotectant.Conclusions：The optimized preparation and formulation can be used to prepare docetaxel liposome successfully. |
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| Keywords: | Doxorubicin-Liposomes freez-drying |
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