酞丁安二氧六环包含物的研究

近年来,对包含化合物(inclusion compound亦称笼形物clathrate)的研究,进展甚快。由于其性质特殊,用途广泛,颇引起注意。本文通过对我国创制的治疗沙眼的新型药物(由中国医学科学院药物研究所研制的酞丁安,化学名为3-酞酰亚胺-2-氧代丁醛-双缩氨硫脲,并含有一定量的二氧六环,结构式为

STUDIES ON THE INCLUSION COMPOUND OF DIOXANE WITH PHTIOBUZONE

Inclusion compounds are the specialized form of molecular compounds. The constituents are usually present in constant, but not necessarily stoichiometric proportions.Phtiobuzone, 2,2'-[1-[1-(1,3(2H) dioxo-1H-isoindol-2yl) ethyl] 1,2-ethanediyldene] bis-hydrazine carbothioamide is a new ophthalmic antiviral agent. During crystallization from dioxane, crystals may consist of dioxane. This compound was studied by a variety of conventional analytical methods including melting behavior, differential thermal analysis and chromatographic analysis. According to the results of these experiments, it may be considered as a complex of dioxane with phtiobuzone and also an inclusion compound. The ratio of the drug to dioxane in the inclusion compound was about 1 : 1.