Role of vasoactive amines in the antitumor activity of endotoxin |
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| Affiliation: | 1. Department of Immunology, Laboratory of Microbiology, State University of Utrecht, The Netherlands;2. Division for Nutrition and Food Research TNO, Institute CIVO Toxicology and Nutrition, Zeist, The Netherlands;1. Teagasc Food Research Centre, Ashtown, Dublin 15, Ireland;2. School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland;1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China;2. National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China;1. Dipartimento di Farmacia, Università “G. d’Annunzio” Chieti - Pescara, Via dei Vestini 31, 66100 Chieti Scalo, CH, Italy;2. Prolabin & Tefarm Srl, Via dell’Acciaio 9, 06134, Perugia, Italy;1. College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun, 130118, China;2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China |
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| Abstract: | To estimate a possible role of vasoamines in the antitumor action of endotoxin, effects of isoproterenol, serotonin and adrenaline on subcutaneosly transplanted murine Meth A sarcoma and the capacity of these agents to elicit antitumor factors were studied. Macroscopically all agents induced tumor necrosis and a temporal tumor growth stop, but only endotoxin was capable of induction of complete tumor regression. Histology showed that all agents induced hyperemia by 4 h and hemorrhagic necrosis by 24 h. The latter was located superficially at the outside of the tumors. Only serotonin and especially endotoxin induced substantial non-hemorrhagic necrosis in the remaining part of the tumors. Endotoxin induced a profound inhibition of the mitotic activity within the tumor, the effect of other agents was considerably less. Only endotoxin induced high levels of tumor necrosis factor, heat stable cytostatic factors and interferon in the circulation of mice treated with Corynebacterium parvum 14 days earlier.It is concluded that these and other data provide indirect but circumstantial evidence for a role of vasoamines in the induction of hyperemia and hemorrhagic necrosis by endotoxin. The latter two effects are probably causally related. It is suggested that non-toxic vasoamines may be useful adjuvants to other treatments of cancer. |
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