奥氮平联合佐匹克隆治疗慢性失眠症的临床疗效研究

目的 探讨对慢性失眠症的有效治疗方法.方法 采用随机对照方法,将120例慢性失眠症患者按随机数字表法随机分为奥氮平联合佐匹克隆组、佐匹克隆组及奥氮平组,治疗8周.采用匹兹堡睡眠质量指数(PSQI)及药物副作用量表评定临床疗效和副作用.结果 奥氮平联合佐匹克隆组在治疗第8周时PSQI总分、汉密顿焦虑量表(HAMD)、汉密顿抑郁量表(HAMA)、临床显效率[分别为(5.1±1.9)分、(11.8±5.9)分、(5.2±2.1)分、90.00%]明显优于单用奥氮平组[分别为(6.1±2.3)分、(11.7±5.3)分、(5.4±1.8)分、71.25%]和佐匹克隆组[(6.7±2.3)分、(17.5±7.8)分、(10.3±6.4)分、71.25%],差异具有显著性(P<0.05).结论 联合应用奥氮平与佐匹克隆能显著提高慢性失眠症患者的临床疗效,而且可以明显减少患者日常功能的缺失.

Clinical effects of olanzapine combine zopiclone on chronic insomnia

Objective To research the effective treatment on chronic insomnia. Methods 120 insomnia patients were randomly divided into olanzapine group,zopiclone group and olanzapine combine zopiclone group,each group included 40 patients which received the treatment respectively for 8 weeks as a course. The clinical effects were evaluated by Pittsburgh sleep quality index(PSQI), and the side effects were estimated by treatment emergence symptoms scale (TESS). Results The olanzapine combine zopiclone group patients were better in total score PSQI,HAMD,HAMA and excellently effective power(discerned for 5.1±1.9,11.8±5.9,5.2±2.1,90.00%) than the olanzapine group's (discerned for 6.1±2.3,11.7±5.3,5.4±1.8,71.25%)and the zopiclone group's(discerned for 6.7±2.3,17.5±7.8,10.3±6.4,71.25%) at the end of 8 weeks treatment,and the difference was statistical significance(P<0.05). Conclusion Combining olanzapine and zopiclone on chronic insomnia can improve treatment effective, and improve the day function significantly.