Nitric oxide synthase inhibition blocks phencyclidine-induced behavioural effects on prepulse inhibition and locomotor activity in the rat |
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Authors: | C Johansson David M Jackson Lennart Svensson |
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Institution: | Department of Behavioural and Biochemical Pharmacology, CNS Preclinical Research and Development, Astra Arcus AB, S-151 85 S?dert?lje, Sweden Fax (+46)8/5532-8889, SE Department of Pharmacology, G?teborg University, G?teborg, Sweden, SE
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Abstract: | The ability of the nitric oxide synthase inhibitor, N
G-nitro-L-arginine methyl ester (L-NAME), to block the behavioural effects of the potent psychotomimetic, phencyclidine, was tested in rats using two different
behavioural models. L-NAME was found to block both phencyclidine-induced disruption of prepulse inhibition of acoustic startle and phencyclidine-induced
stimulation of locomotor activity. A selective action of L-NAME on the effects of phencyclidine was indicated, since L-NAME did not alter the effects of amphetamine, another potent psychotomimetic, in these behavioural models. These observations
suggest that a nitric oxide-dependent mechanism may be involved in the effects of phencyclidine in the central nervous system.
Received: 2 September 1996/Final version: 21 December 1996 |
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Keywords: | Nitric oxide Prepulse inhibition Locomotor activity Schizophrenia Phencyclidine Amphetamine Rat |
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