异氟醚或异丙酚麻醉对血糖及胰岛素浓度的影响

目的 :观察颅脑手术中吸入异氟醚麻醉或静注异丙酚麻醉静脉血血糖及胰岛素浓度的变化。方法 :30例颅内肿瘤切除术病人随机分为异氟醚组与异丙酚组 ,每组 15例。两组诱异用药相同 ;麻醉维持分别为异丙酚或异氟醚。于诱异前、插管后、麻醉维持 30min及 6 0min采静脉血 ,测定血糖和胰岛素浓度。结果 :异丙酚组各时点血糖、异氟醚组各时点胰岛素浓度无显著变化 ;异氟醚组血糖浓度在麻醉后 30及 6 0min明显升高 (P <0 .0 5及P <0 .0 1) ,异丙酚组胰岛素浓度在麻醉后 6 0min显著升高 (P <0 .0 5 )。结论 :异氟醚麻醉下血糖显著升高 ,而异丙酚麻醉血糖无显著变化 ,故异丙酚麻醉较适用于颅脑手术。

The effect or propofol of isoflurane on blood concentration of glucose and insulin during brain tumor resection

Objective: To study the changes of blood concentration of glucose and insulin during brain tumor resection under propofol or isoflurane anesthesia.Methods:Thirty patients scheduled for brain tumor resection were randomized to propofol group (n=15) and isoflurane group (n=15) respectively.Venous blood samples were taken for the measurement of blood concentration of glucose and insulin before induction,after intubation,at 30 and 60 min during anesthetic maintenance respectively.Results:Blood concentration of glucose in propofol group and blood concentration of insulin in isoflurane group were not significantly changed.In isoflurane group,however,blood concentration of glucose increased significantly at 30,60min,( P <0.05 and P <0.01)and in propofol group insulin increased significantly at 60 min ( P <0.05).Conclusion:The blood sugar concentration significantly increases in isoflurane anesthesia,but there is no significant change in propofol anesthesia.Therefore propofol anesthesia is more suitable for brain surgery.