| 超排卵周期卵巢低反应患者卵泡液骨形成蛋白-15水平升高 |
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| 引用本文： | 吴琰婷,陆秀娥,王婷婷,何荣环,徐键,黄荷凤. 超排卵周期卵巢低反应患者卵泡液骨形成蛋白-15水平升高[J]. 浙江大学学报(医学版), 2007, 36(5): 439-442 |
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| 作者姓名： | 吴琰婷 陆秀娥 王婷婷 何荣环 徐键 黄荷凤 |
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| 作者单位： | 浙江大学医学院,附属妇产科医院,浙江,杭州,310006 |
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| 摘 要： | 目的:研究卵泡液中骨形成蛋白-15(BM P-15)的水平及其与超排卵周期卵巢低反应之间的关系。方法:对70例因输卵管性或男性因素不孕而行体外受精-胚胎移植(IVF-ET)的患者,采用本中心常规促超排卵方案,用W estern印迹方法测定取卵时各组卵泡液中BM P-15的水平。按取卵时卵泡发育数目不同,将卵巢对超排卵药物的反应分为低反应型(卵泡数≤3)和正常反应型(卵泡数4~13个)。结果:卵泡液中BM P-15的相对光密度(ROD),低反应组高于正常反应组(1.01±0.34 vs 0.77±0.24,P<0.01),差异有显著性。结论:卵泡液中高BM P-15水平与促排卵周期卵巢低反应的发生有关。
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| 关 键 词： | 卵泡液 超排卵 骨形态发生蛋白质类 卵巢/细胞学 卵巢/代谢 受精,体外 胚胎移植 印迹法,蛋白质 |
| 文章编号： | 1008-9292（2007）05-0439-04 |
| 修稿时间： | 2007-06-06 |
Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels |
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| WU Yan-ting, LU Xiu-e, WANG Ting-ting, et al. Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels[J]. Journal of Zhejiang University. Medical sciences, 2007, 36(5): 439-442 |
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| Authors: | WU Yan-ting LU Xiu-e WANG Ting-ting et al |
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| Affiliation: | The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China |
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| Abstract: | OBJECTIVE: To evaluate the levels of bone morphogenetic protein-15 (BMP-15) in human follicular fluid (FF) and its association with response to ovarian stimulation. METHODS: Western blotting was performed to determine the levels of BMP-15 in FF obtained from follicle aspirates in 70 patients undergoing IVF treatment. According to the response to ovarian stimulation the patients were divided into poor responder group and normal responder group. RESULT: BMP-15 levels in FF of poor responders were significantly higher than those in normal responders (1.01 +/- 0.34 vs 0.77 +/- 0.24, P<0.01). CONCLUSION: Increased levels of BMP-15 in FF may be associated with poor response to ovarian stimulation. |
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| Keywords: | Follicular fluid Superovulation Bone morphogenetic proteins Ovary/cytol Ovary/metab Fertilization in vitro Embryo transfer Western blotting |
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