小剂量卡维地洛治疗老年慢性心力衰竭的疗效观察

目的探讨小剂量卡维地洛对老年（≥60岁）慢性心力衰竭（CHF）患者的疗效。方法将90例经常规心衰治疗病情稳定的老年CHF患者随机分为两组。卡维地洛组50例，在原有治疗基础上加服卡维地洛3．125mg，2次／d；持续2周后，无明显不良反应者加量至6．25mg，2次／d，直到6个月。常规治疗组40例作为对照，采用心力衰竭的标准治疗方案。分别检测两组患者治疗前后心率（HR）、左室射血分数（LvEF）和左室后壁（LVP）、室间隔（IVS）厚度。结果与常规治疗组相比，卡维地洛组患者的HR变慢，LVEF增加，LVP和IVS厚度均减少。结论卡维地洛治疗老年CHF6个月后，具有逆转左室重构和改善心功能的有益作用。

Clinical therapeutic effects of small dosage of carvedilol on elderly patients with chronic heart failure

Objective To study the clinical therapeutic effects and safety of small dosage of carvedilol on chronic heat failure （CHF） in old patients（≥60 y）. Methods Old patients （n=90） who tolerated conventional treat-ment of CHF（diuretics, ACEI, digitalis） were randomly divided into 2 groups.The carvedilol group, 50 patients （M19,F11） were treated with carvedilol 3.125 mg bid for 2 weeks,those without obvious adverse reactions received 6.25 mg bid for 6 months. The conventional group,40 patients （M15,F15） still received conventional teatment as control.We detected patients’ heart rate （HR）,left ventficular ejection fraction （LVEF）, thickness of left ventricular posterior wall（LVP） and interventricular septum（IVS） before and after treatment. Results Compared with the conventional treatment group the HR,thickness of LVP and IVS decreased,LVEF in-creased in THE camedilol treatment group the HR, thickness of LVP and IVS decreased, LVEF in-creased in the caevedilol group after 6 months treatment. Conclusion It has good clinical effects on reversing the left ventricular remodeling and promoting the cardiac function after 6 months treatment of carvedilol in old CHF patients.