幽门螺杆菌感染与冠心病的相关性

目的:探讨幽门螺杆菌(helicobacter pylori,Hp)感染与冠心病之间的关系。方法:研究对象分为:正常对照组(88例)和冠心病组(175例),正常对照组为冠状动脉造影(CAG)正常者;冠心病组经CAG证实冠状动脉狭窄程度超过50%,且排除Hp感染根治史或者恶性肿瘤的病史。我们通过胃十二指肠镜活检制作胃窦部组织切片,War-thin-starry银染色确定Hp感染。结果:两组间观测指标性别、年龄、吸烟和高密度脂蛋白胆固醇(HDL-C)差异具有统计学意义。正常对照组中28例(32%)和冠心病组73例(42%)伴有Hp感染,但差异不具有统计学意义。随访行经皮冠状动脉介入治疗的冠心病患者82例,半年复查CAG,59例Hp阴性的患者有21例(36%)出现新的冠状动脉病变或支架内再狭窄,23例Hp阳性的患者有12例(52%)出现新的冠状动脉病变或支架内再狭窄,两组间差异不具有统计学意义。结论:本研究没有明确Hp感染与冠心病的关系,有待进一步研究。

Relationship between Helicobacter pylori infection and coronary artery disease

AIM:To investigate the relationship between Helicobacter pylori(Hp) infection and coronary artery disease(CAD).METHODS:There were 263 cases divided into two groups.There were 88 cases in the normal group and 175 cases in the CAD group.Patients in the CAD group had >50% coronary stenosis diagnosed by coronary angiography.Those patients with a history of previous Hp eradication and/or malignancy were ruled out.The tissue was acquired by gastroduodenoscopic biopsy and then stained by Warthin-starry silver stain.RESULTS:There were significant differences between groups in gender,age,smoking habit and high-density lipoprotein cholesterol(HDL-C).There was no statistical difference in Hp infection ratio between groups(32% vs.42%).Six months later,82 patients of the CAD group who had been treated by percutaneous coronary intervention(PCI) experienced angiography once again.Twenty-one(36%) of the 59 patients of the Hp-negative group and 12(52%) of the 23 patients of the Hp-positive group experienced new coronary stenotic lesion and in-stent restenosis.There was no statistical significance.CONCLUSION:There was no definite relationship between Hp infection and CAD.Further studies are needed in this area.