| 两性霉素B和5—氟胞嘧啶合用对隐球菌脑膜炎患者外周血象的影响 |
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| 引用本文： | 谢春英,李建国,谢仕斌,蔡少贤. 两性霉素B和5—氟胞嘧啶合用对隐球菌脑膜炎患者外周血象的影响[J]. 中国临床药学杂志, 2001, 10(1): 6-8 |
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| 作者姓名： | 谢春英 李建国 谢仕斌 蔡少贤 |
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| 作者单位： | 1. 广州市第六人民医院药剂科 广州 510655
2. 中山医科大学附属第三医院传染科 广州 510630 |
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| 摘 要： | 目的：探讨两性毒素B（AMB）联合5-氟胞嘧啶（5-FC）治疗新型隐球菌性脑膜炎时对患者外周血象的影响。方法：用AMB联合5-FC治疗新型隐球菌性脑膜炎患者30例，观察用药前后外周血象变化。结果：患者治疗后中轻度贫血发生率为80%，白细胞减少症和血小板减少症的发生率分别为13.4%（4/30）和6.7%(2/30）。结论：AMB联合5-FC治疗新型隐球菌性脑膜炎时对外周血象的影响主要为贫血，外周血象的变化不是需要中断病原治疗的主要因素。
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| 关 键 词： | 两性霉素B 5－氟胞嘧啶 骨髓毒性 隐球菌性脑膜炎 |
| 文章编号： | 1007-4406(2001)01-006-03 |
| 修稿时间： | 2000-07-11 |
Influence on peripheral blood figure from combined amphotericin B and flucytosine in patients with cryptococcus meningitis |
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| Xie Chunying ,Li Jianguo ,Xie Shibin ,Cai Shaoxian. Influence on peripheral blood figure from combined amphotericin B and flucytosine in patients with cryptococcus meningitis[J]. Chinese Journal of Clinical Pharmacy, 2001, 10(1): 6-8 |
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| Authors: | Xie Chunying Li Jianguo Xie Shibin Cai Shaoxian |
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| Affiliation: | Xie Chunying 1,Li Jianguo 2,Xie Shibin 2,Cai Shaoxian 1 |
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| Abstract: | AIM: To observe the influence on peripheral blood figure by amphotericin B (AMB) combined with flucytosine (5 FC) in the treatment of the patients with cryptococcus meningitis. METHODS: Thirty patients with cryptococcus meningitis treated by AMB combined with 5 FC were evaluated. Their peripheral blood figures were observed regularly before and after treatment. RESULTS: The results showed that 80% (24/30) of patients appeared mild or middle anaemia, the incidence rate of neutropenia and thrombocytopenia were 13 3% (4/30) and 6 7% (2/30) respectively. CONCLUSION: The influence on peripheral blood figure from AMB combined with 5 FC in the treatment of the patients with cryptococcus meningitis is anaemia. The change of peripheral blood figure is not the main reason to stop treating. |
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| Keywords: | amphotericin B flucytosine toxicity of marrow cryptococcus meningitiD |
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