53例涎腺腺样囊性癌MMP—2和MMP—9表达与神经浸润和淋巴结转移的关系

目的研究涎腺腺样囊性癌MMP-2和MMP-9表达情况，评估其与涎腺腺样囊性癌神经浸润和淋巴结转移的关系。方法选取53例涎腺腺样囊性癌，以抗MMP-2和MMP-9单克隆抗体用Envision法进行免疫组织化学染色和半定量分析。结果MMP-2和MMP-9在涎腺腺样囊性癌中的表达率分别为67.92％和79.25％；有神经浸润的腺样囊性癌其MMP-2和MMP-9的表达水平远高于无浸润者(P＜0.05，P＜0.05)；随着MMP-2和MMP-9的表达水平增高，淋巴结转移率也增高(P＜0.05，P＜0.05)。结论提示MMP-2和MMP-9的高表达与涎腺腺样囊性癌易侵犯神经的特性及发生淋巴结转移密切相关。

Expression of MMP-2 andMMP-9 in 53 Cases of Salivary Adenoid Cystic Carcinoma and Its Relationship with Invasionand Metastasis

Purpose To study the patterns of the expression of MMP?2 and MMP?9 in human salivary adenoid cystic carcinoma and evaluate the relationship between the expression and nerve invasion and lymph node metastasis. Methods The immunohistochemical location of MMP?2 and MMP?9 was evaluated by using Envision immunoperoxidase technique.Studies were performed in 53 surgical excised specimens.The immunohistochemical staining results were densitometrically semiquantitatived. Results The expressions of MMP?2 and MMP?9 in salivary adenoid cystic carcinoma were 67.92% and 79.25% respectively.The MMP?2 and MMP?9 levels in salivary adenoid cystic carcinoma with nerve invasion were much higher than those without invasion( P <0.05, P <0.05 respectively),and the percentage of lymph node metastasis rose with the change of MMP?2 and MMP?9 ( P <0.05, P <0.05 respectively). Conclusions The results indicate that the rise of MMP?2 and MMP?9 correlate with the nerve invasion and lymph node metastasis.