异构体(R,R)-XY和(S,S)-XY对兔眼血流的影响 |
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引用本文: | 彭洁,;邹艳红,;江伟,;计晓斌,;陈欣宇,;张奕华,;彭司勋,;邱春亿.异构体(R,R)-XY和(S,S)-XY对兔眼血流的影响[J].美中国际眼科杂志,2008(3):437-441. |
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作者姓名: | 彭洁 ;邹艳红 ;江伟 ;计晓斌 ;陈欣宇 ;张奕华 ;彭司勋 ;邱春亿 |
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作者单位: | [1]美国得克萨斯农工大学医学院眼科药理研究所; [2]中国药科大学新药物研究中心,中国江苏省南京市210009 |
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基金项目: | 中国国家自然科学基金资助项目(No.30472085);美国德州农工大学医学院眼科药理研究所资助. |
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摘 要: | 目的:研究两组异构体(R,R)-XY-1到(R,R)-XY-12以及(S,S)-XY-1到(S,S)-XY-12对兔眼血流的影响。
方法:用彩色微球技术测量兔眼在高眼压下(40mmHg)各组织的血流情况。
结果:12个(R,R)-XY化合物以10g/L,50μL的剂量滴入兔眼,其中4个化合物可提高脉络膜血流。所有(S,S)-XY系列的化合物对兔眼血流没有影响。
结论:(R,R)-XY系列中一些化合物可以增加兔眼血流,这些可能对眼部血流降低相关疾病的防治有作用。在24个化合物中,(R,R)-XY-1和(R,R)-XY-9最有药效。
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关 键 词: | 眼血流 缺血 异构体 |
Effects of enantiomers (R,R)-XY and (S,S)-XY on ocular blood flow in rabbits |
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Institution: | Jie Peng, Yan-Hong Zou, Wei Jiang,Xiao-Bin Ji , Xin- Yu Chen , Yi-Hua Zhang ,Si-Xun Peng , George C Y Chiou (1 Institute of Ocular Pharmacology and Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University System Health Science Center, College Station, TX 77843, USAl 2 Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, Jiangsu Province, China) |
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Abstract: | AIM: To evaluate the effects of two series of enantiomers (R, R)-XY-1 through (R, R)-XY-12 and (S, S)-XY-1 through (S, S)-XY-12] on ocular blood flow in rabbits. METHODS: Colored microsphere technique was used for in vivo experiments to determine the ocular blood flow in various tissues of ocular hypertensive (40mmHg) rabbit eyes. RESULTS: Of the twelve compounds of (R, R)-XY series examined, four increased choroidal blood flow at 10g/L, 50μL instilled into eyes. All compounds of (S, S)- XY series were not effective on ocular blood flow. CONCLUSION: Some compounds of (R, R)-XY series increased the ocular blood flow, which might be useful for the prevention and treatment of ocular blood flow related eye diseases. Among all twenty-four compounds, (R, R)-XY-1 and (R, R)-XY-9 seem to be the most potent ones. |
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Keywords: | ocular blood flow ischemia enantiomer |
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