Antiviral effect of chinonin against herpes simples virus |
| |
Authors: | Jiang Jie Li Sha Li Ming and Xiang Jizhou |
| |
Institution: | (1) Department of Pharmacology, School of Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, 130030 Wuhan, China;(2) Department of Pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;(3) Sanjiu Medical & Pharmaceutical Co. Ltd., 518029 Shenzhen, China;(4) Present address: Sanjiu Medical. & Pharmaceutical Co. Ltd., 518029 Shenzhen, China |
| |
Abstract: | Summary In order to investigate the antiviral effect of chinonin against Herpes simplex virus (HSV), the encephalitis model in mice
and skin infection model in guinea pigs were established by HSV-1 and HSV-II infection respectively. Acyclovir was used as
the positive reference drug to evaluate the antiviral capacity of chinonin. Chinonin showed an obvious therapeutic effect
on encephalitis in mice at doses of 25 and 50 mg/kg. At both dosages, chinonin demonstrated stronger protection than acyclovir
(1 and 5 mg/kg) to the infected mice from death. It was also found that chinonin could treat the skin infection in guinea
pigs effectively. The therapeutic effect of chinonin was similar to that of acyclovir (5 mg/kg) at 25 mg/kg but obviously
better than that at 50 and 75 mg/kg. In conclusion, chinonin is a potential candidate for the treatment against HSV.
JIANG Jie, male, born in 1973. M.D., Ph.D. |
| |
Keywords: | chinonin acyclovir Herpes simplex virus encephalitis skin infection |
本文献已被 SpringerLink 等数据库收录! |
|