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The Role of Behavioral and Neurocognitive Functioning in Substance Use Among Youth with Perinatally Acquired HIV Infection and Perinatal HIV Exposure Without Infection |
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| Authors: | Nichols Sharon L. Brummel Sean Malee Kathleen M. Mellins Claude A. Moscicki Anna-Barbara Smith Renee Cuadra Anai M. Bryant Kendall Boyce Cheryl Anne Tassiopoulos Katherine K. |
| Affiliation: | 1.Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, Mail Code 0935, La Jolla, CA, 92093, USA ;2.The Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA, USA ;3.Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, Chicago, IL, USA ;4.Department of Psychiatry, HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY, USA ;5.Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA ;6.Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA ;7.Department of Clinical Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA ;8.National Institutes of Health, Bethesda, MD, USA ;9.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA ; |
| Abstract: | This study examined associations of self-regulatory behavior and cognitive functioning with substance use (SU) to inform interventions for youth with perinatal HIV infection (YPHIV) or exposure but uninfected (YPHEU). Youth aged 7–15 years (YPHIV, n?=?390; YPHEU, n?=?211) were followed longitudinally with cognitive testing and behavioral questionnaires including self-report of alcohol, marijuana, tobacco, and other SU. Cox proportional hazards analyses were used to examine correlates of initiating each substance for those without prior use at baseline and generalized estimating equation analyses were used to address associations of cognitive/behavioral measurements with SU prevalence for the entire sample. Lower self-reported self-regulation skills, but higher cognitive functioning abilities, were associated with initiation and prevalent use of alcohol and marijuana regardless of HIV status. Our findings suggest SU screening tools and self-regulation interventions developed for general adolescent populations should be implemented for those with PHIV, who may be at heightened risk for SU-related health consequences. |
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