中药与肠道菌群相互作用的研究进展

<正>肠道菌群是一个大型微生物群，具有增强肠道完整性、吸收能量、抵御病原体入侵等生理功能^1-2]。人类许多疾病如肥胖、2型糖尿病、非酒精性肝病等均与肠道菌群存在相关性^3]。近年来，肠道菌群已成为研究疾病发生和进程的热点方向。中药与肠道菌群之间存在着相互作用，中药口服后对肠道菌群结构、丰度等起到调节作用，同时肠道菌群能产生各种代谢酶，特异性地参与中药有效成分的物质代谢与化学结构重塑，

Research progress on cross talk of traditional Chinese medicine with intestinal flora

Interaction between Traditional Chinese medicine (TCM) and intestinal flora has raised public attention, especially in the area of pharmacology and pharmacokinetics. Many studies demonstrated that oral TCM could cross talk with intestinal flora. Active ingredients and endophytes ofTCM could regulate the composition and abundance of intestinal flora to treat disease. Meanwhile, intestinal flora could bio-transform and modify the active ingredients of TCM, causing different bio-availability, pharmacological effects and toxicity of TCM metabolites. In addition, fecal bacteria transplantation is one of the essential methods to verify the regulation effect of TCM on intestinal flora. Thus, we summarized the interaction of TCM with intestinal flora, and discussed the bio-active ingredients and mechanism of the interaction. The aim of this review is to provide a reference on discovery of new drugs and the action mechanism of TCM.