MG患者外周血单个核细胞TNIP1蛋白、血清AGR、血浆PDGF的变化与其病情程度的关系

目的探讨重症肌无力(MG)病情与外周血单个核细胞中肿瘤坏死因子α诱导蛋白3交互作用蛋白1(TNIP1)蛋白、血清白球蛋白比值(AGR)、血浆血小板源性生长因子(PDGF)变化的关系。方法选取本院2014年1月至2017年1月收集的90例MG患者(MG组)、选取健康体检对象90例(对照组),检测并比较两组对象的外周血单个核细胞中TNIP1蛋白、血清AGR、血浆PDGF,并分析上述指标在不同类型MG患者中的差异及与重症肌无力定量评分(QMGS)的相关性。结果MG组患者的TNIP1蛋白、血清AGR、血浆PDGF水平均显著的低于对照组,差异具有统计学意义(P<0.05);眼肌型MG组患者的TNIP1蛋白、血清AGR、血浆PDGF水平均显著的高于全身型MG患者,差异具有统计学意义(P<0.05),眼肌型MG患者QMGS评分显著的低于全身型MG患者(P<0.05);MG组患者的TNIP1蛋白、血清AGR、血浆PDGF水平与患者的QMGS评分均呈显著的负相关关系(P<0.05);采用多元线性回归分析,QMGS评分=38.062-5.571(TNIP1蛋白)-2.664(AGR)-0.883(PDGF)。结论MG患者外周血TNIP1蛋白、血清AGR、血浆PDGF水平降低显著,并且与患者病情加重有关。

Relationship between changes of TNIP1 protein,serum AGR and plasma PDGF in peripheral blood mononuclear cells of MG patients and their severity

Objective To investigate the changes of myasthenia gravis(MG)and tumor necrosis factor alpha⁃inducing protein 3 interaction protein 1(TNIP1)in peripheral blood mononuclear cells,serum albumin ratio(AGR),and platelet⁃derived growth factor(PDGF).Methods 90 MG patients(MG group)were collected from our hospital from January 2014 to January 2017,and 90 healthy control subjects(control group).TNIP1 in peripheral blood mononuclear cells,serum AGR,and plasma PDGF were detected and compared between the two groups of subjects,and the differences between the above indicators in different types of MG patients and their correlation with quantitative myasthenia gravis score(QMGS)were analyzed.Results The patients in the MG group of TNIP1,serum AGR and plasma PDGF levels were significantly lower than those in control group(P<0.05).MG group of patients with ocular type TNIP1,serum AGR and plasma PDGF levels were significantly higher than that in patients with systemic MG,the differences were statistically significant(P<0.05),QMGS patients with ophthalmoplegia MG score was significantly lower than that of patients with systemic MG(P<0.05).The levels of TNIP1 protein,serum AGR,and plasma PDGF in patients in the MG group were significantly negatively correlated with the patients􀆳QMGS scores(P<0.05).Using multiple linear regression analysis,QMGS score is 38.062-5.571(TNIP1 protein)-2.664(AGR)-0.883(PDGF).Conclusion The levels of TNIP1 in the peripheral blood,serum AGR and plasma PDGF of MG patients were significantly decreased,and were related to the worsening of the patient􀆳s condition.