影响补救性卵胞浆内单精子注射周期妊娠的因素

常规体外受精（IVF）周期中不受精或者低受精（周期受精率≤25％）在临床上的发生率一般占常规IVF的10％～30％，补救性卵胞浆内单精子注射（rescue—ICSI）作为一种受精失败的补救措施在临床上的应用已有十余年，但rescue—ICSI的临床结局不如人意，对于这部分患者，目前国内外仍无有效的改善措施。本文通过对rescue～ICSI周期的回顾，分析影响周期妊娠的因素，为临床实践提供参考。

Influential factors on pregnancies of the rescue intracytoplasmic sperm injection cycles

Objective. To investigate the predictive factors of pregnancy of rescue-ICSI cycles. Method.. Data of rescue-ICSI cycles due to the fairlure or very low rate of fertilization between January 2004 and December 2007 were retrospectively analyzed. The differences between pregnant cycles （9 cycles） and non-pregnant cycles （97 cycles） were compared, and the predictive values of ordinary clinical factors on pregnancy were evaluated. Result： The number of M Ⅱ oocytes was an independent predictor for pregnancy in rescue ICSI cycles （OR=1. 215,P=0. 002）. The cycles with M Ⅱ oocytes ≥20 had a higher pregnancy rate than the cycles with less（66.7% vs 5.0%） （P〈0.01）. Conclusion： The number of M Ⅱ oocytes was an independent predictors for pregnancy in rescue ICSI cycles, it could improve the clinical outcome to selected patients by this predictor.