| 卡尼汀对失血性休克兔复苏过程中血乳酸和剩余碱变化的影响 |
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| 引用本文： | 刘侃,陈琪,周红,宋国林,余煜豪.卡尼汀对失血性休克兔复苏过程中血乳酸和剩余碱变化的影响[J].青海医药杂志,2009,39(8):2-5. |
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| 作者姓名： | 刘侃 陈琪 周红 宋国林 余煜豪 |
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| 作者单位： | 遵义医学院第五附属(珠海)医院急诊科,519100 |
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| 基金项目： | 申请研究计划课题种类:珠海市2008年科技局基金项目 |
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| 摘 要： | 目的：观察卡尼汀对失血性休克兔复苏过程中血乳酸和剩余碱变化的影响,以评估其对失血性休克复苏的作用。方法：24只家兔随机分成4组：生理盐水组、生理盐水加卡尼汀组、高渗盐溶液组和高渗盐溶液加卡尼汀组,在休克前（T1）、休克末期（T2）、复苏后1h（T3）、2h（T4）、4h（T5）、6h（T6）时间点对家兔的平均动脉压、心率进行检测,抽取血液进行血乳酸（BL）、剩余碱（BE）的测定。结果：复苏后,各组BL值随时间呈现逐渐下降,生理盐水加卡尼汀组各时间点BL显著低于生理盐水组（P〈0.05）,生理盐水加卡尼汀组在复苏后2小时BL下降最为明显（6.97±2.56）mmol/L,在4小时又有小幅度升高（7.84±1.84）mmol/L。高渗盐溶液加卡尼汀组在复苏后1小时及2小时BL值明显低于高渗盐组（P〈0.01）,复苏后整体的BL值变化与高渗盐组没有显著差别。结论：在失血性休克复苏早期使用卡尼汀,对减少乳酸的生成、保护组织细胞,减少因无氧代谢所造成的损伤有一定的意义。
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| 关 键 词： | 失血性休克 卡尼汀 血乳酸 |
Effect of Carnitine on Blood Lactic Acid and Base Excess in Resuscitation of Hemorrhagic Shock Rabbits |
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| Liu Kan,Chen Qi,Zhou Hong,Song Guolin,Yu Yuhao The Fifth Affiliated Hospital of Zunyi Medical College.Effect of Carnitine on Blood Lactic Acid and Base Excess in Resuscitation of Hemorrhagic Shock Rabbits[J].Qinghai Medical Journal,2009,39(8):2-5. |
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| Authors: | Liu Kan Chen Qi Zhou Hong Song Guolin Yu Yuhao The Fifth Affiliated Hospital of Zunyi Medical College |
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| Institution: | Liu Kan,Chen Qi,Zhou Hong,Song Guolin,Yu Yuhao The Fifth Affiliated(Zhuhai) Hospital of Zunyi Medical College(519100) |
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| Abstract: | Objective:To assess the effect of carnitine on resuscitation of hemorrhagic shock through change of blood lactic acid(BLA) and base excess(BE).Methods:24 models of hemorrhagic shock rabbits were made and divided into four groups of 6 animals each:the NS(normal saline) group,NS plus carnitine group,HS(hypertonic saline) group and HS plus carnitine group.The average artery pressure,heart rate,BLA level and BE level were measured before and after shock as well as 1h,2h,4h and 6h after resuscitation.Results:Aft... |
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| Keywords: | Hemorrhagic Shock Carnitine Blood lactic acid Rabbites |
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