| 芦丁固体分散体的制备及其溶出特性考察 |
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| 引用本文： | 孙磊,马晓兰,吴洋,孙涛,戴贵东.芦丁固体分散体的制备及其溶出特性考察[J].中国实验方剂学杂志,2013,19(6):23-25. |
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| 作者姓名： | 孙磊 马晓兰 吴洋 孙涛 戴贵东 |
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| 作者单位： | 宁夏医科大学药学院,银川 750004;青铜峡市人民医院药剂科,宁夏 青铜峡 751600;宁夏医科大学药学院,银川 750004;宁夏医科大学药学院,银川 750004;宁夏医科大学药学院,银川 750004 |
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| 基金项目： | 宁夏医科大学青年基金项目(XQ200907) |
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| 摘 要： | 目的:制备芦丁固体分散体,比较不同载体对芦丁固体分散体体外溶出度的影响。方法:采用溶剂法制备固体分散体并考察其体外溶出度;考察不同载体对芦丁溶出度的影响,以差示热分析药物在载体中的存在状态。结果:载体种类和用量对芦丁溶出影响显著,其中PVPK30作为载体时溶出效果最佳,芦丁以微晶无定形分散于载体中。结论:溶剂法制得固体分散体中芦丁的溶出度和溶出速率均显著提高。
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| 关 键 词： | 芦丁 固体分散体 熔融法 载体 |
| 收稿时间： | 2012/2/28 0:00:00 |
Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions |
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| SUN Lei,MA Xiao-lan,WU Yang,SUN Tao and DAI Gui-dong.Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions[J].China Journal of Experimental Traditional Medical Formulae,2013,19(6):23-25. |
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| Authors: | SUN Lei MA Xiao-lan WU Yang SUN Tao and DAI Gui-dong |
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| Institution: | College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China;Pharmacy Department, The People's Hospital of Qingtongxia, Qingtongxia 751600, China;College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China;College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China;College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China |
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| Abstract: | Objective: To prepare rutin solid dispersions(RSD), and compare influence of different carriers on in vitro dissolution of it. Method: RSD was prepared by solvent method and its in vitro dissolution was tested.Influence of different carriers on drug dissolution was evaluated.Differential scanning calorimetry (DSC) was used to examine presence state of rutin in carrier. Result: Types and amount of carriers had significant influence on rutin dissolution, PVPK30 was chosen as optimum carrier, DSC showed that rutin dispersed in PVPK30 with amorphous and microcrystalline. Conclusion: Rutin dissolution and dissolution rate of these prepared rutin-PVPK30 solid dispersions were significantly improved. |
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| Keywords: | rutin solid dispersions melting method carrier |
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