丹参注射液对2型糖尿病下肢血管病变患者CRP,IL-6水平的影响

目的:探讨丹参注射液对2型糖尿病下肢血管病变患者炎症指标的影响。方法:回顾性分析我院2006年1月至2011年12月收治入院的糖尿病下肢血管病变80例临床资料,采用随机、双盲、双模拟、阳性药物平行对照方法,按1∶1比例随机分为治疗组和对照组各40例,对照组给与常规治疗,治疗组在常规治疗基础上加用丹参注射液,观察两组治疗前后血清炎症因子C反应蛋白(CRP)、白细胞介素6(IL-6)水平的变化,并选择我院同期收治无下肢血管病变的2型糖尿病患者40例(非治疗组)进行对比。结果:糖尿病下肢血管病变患者血清CRP,IL-6水平明显高于糖尿病无下肢血管病变患者,治疗组治疗后血清CRP,IL-6水平明显低于对照组(P<0.05)。结论:2型糖尿病下肢血管病变患者炎症指标明显升高,丹参注射液对炎症因子的干预效果显著。

Influence of Danshen Injection on CRP, IL-6 Levels in Patientss of Type 2 Diabetes with Lower Extremities Vascular Lesion

Objective: To investigate influence of Danshen injection (DI) on inflammatory indexes in patients of type 2 diabetes with vascular lesions of lower extremities. Method: Retrospective analysis was carried out for 80 patients admitted to our hospital from January 2006 to December 2011 with diabetic vascular lesion of lower limbs.Randomized, double-blind, double-dummy, positive drug parallel control method were used.According to the ratio of 1: 1 the patients were randomly divided into treatment group and control group with 40 cases in each group.The control group was given conventional therapy, while the treatment group was given DI combined with conventional therapy.Serum inflammatory factor C reactive protein (CRP), interleukin 6(IL-6) levels in the two groups before and after treatment were analized.Meanwhile, another 40 cases of type 2 diabetics without lower extremity vascular disease as the non-treatment group were compared. Result: Serum CRP, IL-6 levels in patients of diabetes mellitus with vascular lesions in the lower extremities were significantly higher than those in diabetic patients without vascular lesions.Serum CRP, IL-6 levels after treatment were significantly lower than those in the treatment group (P<0.05). Conclusion: Inflammatory indexes in patients of type 2 diabetes with vascular lesions in lower extremities were increased significantly.DI intervention is effective for lowing the inflammatory indexes.