中药配合抗生素治疗中老年下呼吸道耐药细菌感染

目的:探讨痰热清注射液和复方丹参注射液配合抗生素对中老年下呼吸道耐药细菌感染的临床疗效。方法:647例患者按自然队列分为观察组和对照组。经痰培养加药敏培养,观察组(284例)出现54例耐药细菌者,对照组(363例)出现72例耐药细菌者。两组均经验性使用抗生素治疗,并根据药敏结果进行调整,观察组加用痰热清注射液和复方丹参注射液进行治疗,均为20 mL加入0.9%氯化钠注射液250 mL,静脉滴注,1次/d,疗程14 d。观察临床症状、体征及痰细菌清除率。结果:共出现耐药126例患者,占19.47%(126/647),耐药病原菌均以革兰阴性杆菌为主;治疗后4,14 d观察组症状体征积分低于对照组(P<0.05,P<0.01);观察组疾病疗效优于对照组(P<0.05);观察组细菌学疗效优于对照组(P<0.01)。结论:痰热清注射液与复方丹参注射液对下呼吸道耐药细菌有抑制或治疗作用,与抗生素配合使用能减轻临床症状、体征,提高临床疗效。

Traditional Chinese Medicine Combined with Antibiotic in Treatment of Drug-resistant Bacterial Infections of Lower Respiratory Tract in Elderly

Objective: To investigate the clinical efficacy of Tanreqing injection and Compound Danshen injection combined with antibiotic for treatment of drug-resistant bacterial infections of the lower respiratory tract in elderly. Method: Six hundred and forty-seven patients formed a natural team cases according to whether the use of traditional Chinese medicine(Tanreqing injection and Compound Danshen injection).After drug-resistant screening, 54 cases of drug-resistant bacteria in the observation group (total 284 cases) and 72 cases in the control group(total 363 cases).Both groups were treated with antibiotics empirically, and make adjustments based on susceptibility results.The observation group was treated with Tanreqing injection and Compound Salvia injection(20 mL in 250 mL normal saline, iv dripping) for 14 days.Clinical symptoms, signs, and sputum bacterial clearance rate were investigated. Result: There were 126 cases of drug-resistant patients, accounting for 19.47%(126/647).Resistant pathogens were gram-negative bacilli.The symptoms of physical disease integral in the observation group was lower than that in the control group after 4 d and 14 d of treatment(P<0.05 and P<0.01).The efficacy of the observation group was better than that of the control group(P<0.05).Bacteriological efficacy of the observation group was better than that of the control group(P<0.01). Conclusion: Tanreqing injection and Danshen injection combined with antibiotics can inhibit and treat drug-resistant bacterial infections of the lower respiratory tract, and reduce the clinical symptoms and signs, improve the clinical efficacy.