| 观察蒙药额尔敦乌日勒对兔视网膜缺血再灌注损伤的保护作用 |
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| 引用本文： | 乌仁图雅,鲍红艳.观察蒙药额尔敦乌日勒对兔视网膜缺血再灌注损伤的保护作用[J].世界科学技术,2008,10(1):125-128. |
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| 作者姓名： | 乌仁图雅 鲍红艳 |
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| 作者单位： | [1]内蒙古医学院,呼和浩特010110 [2]内蒙古中蒙医院,呼和浩特010020 |
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| 摘 要： | 目的：通过观察兔视网膜缺血再灌注（RIR）损伤后,视网膜中丙二醛（MDA）含量、超氧化物歧化酶（SOD）活性和形态学的变化来探讨蒙药额尔敦乌日勒对RIR损伤的保护作用。方法：将60只日本大耳白兔随机分为正常组、模型组、蒙药组及维生素E组。采用升高兔眼压到110mmHg持续60分钟的方法制作视网膜缺血再灌注模型。分别在缺血再灌注24、72、168h后测定视网膜中MDA含量和SOD活性,并作光镜切片进行形态学观察。结果：模型组视网膜的内核层变薄、细胞排列紊乱,神经节细胞明显减少、有大量空泡形成,伴随MDA含量升高和SOD活性下降。上述变化随时间延长而加重。而蒙药组内核层和神经节细胞层分别比模型组、维生素E组增厚,细胞排列整齐。MDA含量比模型组、维生素E组均明显降低,SOD活性明显升高。结论：蒙药额尔敦乌日勒能降低视网膜中MDA含量、升高SOD活性。能够清除自由基,减轻视网膜组织损伤,对视网膜缺血再灌注损伤具有保护作用。
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| 关 键 词： | 额尔敦乌日勒 视网膜 缺血再灌注损伤 丙二醛 超氧化物歧化酶 |
Protective Effects of Eerduiwu Geriletu on Rabbits' Retinal Ischemia-Reperfusion Injury |
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| WuRentuya,Bao Hongyan.Protective Effects of Eerduiwu Geriletu on Rabbits'' Retinal Ischemia-Reperfusion Injury[J].World Science and Technology(Modernization of Traditional Chinese Medicine),2008,10(1):125-128. |
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| Authors: | WuRentuya Bao Hongyan |
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| Institution: | WuRentuya (Inner Mongolian Medical College Hohhot 010110) Bao Hongyan ( Chinese , Mongolia Hospital of Inner Mongolia Hohhot 010020 ) |
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| Abstract: | We studied malondialdehyde (MDA) content, SOD activity, and morphological changes in rabbits' retina, after a retinal ischemia-reperfusion (RIR)injury, in an attempt to understand the protective effects of Eerduiwu Geriletu, a Mongolian medicine, on RIR injury. In the study, 60 Japanese white rabbits were randomly divided into 4 groups, including normal, model, Mongolian medicine, and vitamin E groups. A method of elevating intraocular pressure of rabbits up to 110mmHg for 60 minutes was employed to make a ... |
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| Keywords: | Eerduiwu Geriletu retina ischemia-reperfusion injury malondialdehyde SOD |
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