三维适形放疗技术对宫颈癌患者生活质量的影响

目的:探讨三维适形放疗技术对宫颈癌患者生存质量的影响。方法:利用三维适形放射治疗计划系统,对60例宫颈癌根治术后需行放疗的患者,建立剂量体积直方图和计量参数,比较两种不同放疗技术的放疗并发症及计算存活率。结果:应用适形技术,正常组织平均并发症概率从0.11减至0.03。肾脏的受照量、直肠反应发生率、膀胱反应、远期并发症两组比较差异有显著性。结论:三维适形治疗技术能显著减少小肠受照体积,对直肠、膀胱受照量的降低也具有优势,可提高肿瘤区域的剂量,提高肿瘤控制率而不会增加正常组织的毒性反应。

Effect of three-dimensional conformal radiotherapy on the living quality of cervical cancer patients

Objective:To investigate the effect of conformal three-dimensional radiotherapy on living quality of of cervical cancer patients.Methods:A 3D 4-field conformal radiotherapy plan was used to establish the dose-volume histograms and dose parameters,and to compare the complication of radiotherapy and the survival rate,based on 60 cases of cervical cancer patients and conventional and 3D conformal radiotherapy methods.Results:The mean normal tissue complication probability(NTCP)decreased from 0.11 to 0.03 with the 3D conformal plan.The mean median dose to the kidneys,the rectum and bladder infections,and long-term complication were significantly different for the two comparative groups(P<0.05).Conclusion:The small bowel dose can be significantly reduced with 3D treatment planning,as well as rectum.The 3D treatment allows dose escalation to the tumor region without increasing toxicity for the critical organs.