Intravascular large B-cell lymphoma secondary to lymphoplasmacytic lymphoma: a case report and review of literature with clonality analysis |
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| Authors: | Yosuke Tanaka Yukio Kobayashi Akiko Miyagi Maeshima Sung Yong Oh Junko Nomoto Suguru Fukuhara Hideaki Kitahara Wataru Munakata Tatsuya Suzuki Dai Maruyama Kensei Tobinai |
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| Institution: | 1Department of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan;2Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan;3Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea |
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| Abstract: | Intravascular large B-cell lymphoma (IVLBCL) can be a fatal malignancy mainly because of difficulty in early detection. Due to the lack of specific clinical manifestations, early detection of IVLBCL remains a challenge, especially in the presence of comorbidities. Lymphoplasmacytic lymphoma (LPL) is an indolent B-cell lymphoma accompanied by monoclonal immunoglobulin M protein in most patients, and known to be associated with high risk of secondary hematological malignancies. Here, we report a patient who developed IVLBCL during treatment for LPL that presented a diagnostic challenge. Rearrangement analysis of the immunoglobulin heavy chain revealed the different clonal origins of two lymphomas, implying a predisposition of LPL to develop unrelated secondary lymphoma. Secondary lymphoma including IVLBCL during the treatment for LPL deserves consideration in order to facilitate early diagnosis and intervention. |
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| Keywords: | Intravascular large B-cell lymphoma lymphoplasmacytic lymphoma secondary lymphoma immunoglobulin rearrangement |
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