| 脂蛋白脂酶在胰岛素抵抗和动脉粥样硬化的发病中的矛盾作用 |
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| 引用本文： | 葛光岩,姚福梅. 脂蛋白脂酶在胰岛素抵抗和动脉粥样硬化的发病中的矛盾作用[J]. 医学综述, 2006, 12(23): 1431-1433 |
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| 作者姓名： | 葛光岩 姚福梅 |
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| 作者单位： | 1. 大连市第二人民医院内分泌科,辽宁,大连,116011
2. 大连市第二人民医院心内科,辽宁,大连,116011 |
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| 摘 要： | 脂蛋白脂酶为甘油三酯代谢的限速酶,脂蛋白脂酶因活性和含量而改变其脂解功能,影响全身脂质代谢和分布,产生的血脂紊乱、高甘油三酯血症、低HDL血症是胰岛素抵抗和动脉硬化的基础。同时,脂蛋白脂酶对动脉粥样硬化和胰岛素抵抗形成具有截然不同的矛盾作用。
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| 关 键 词： | 脂蛋白脂酶 胰岛素抵抗 动脉粥样硬化 |
| 文章编号： | 1006-2084（2006）23-1431-03 |
| 收稿时间： | 2006-03-21 |
| 修稿时间： | 2006-11-28 |
The Contradictive Effects of Lipoprotein Lipase in Insulin Resistance and Atherogenesis |
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| GE Guang-yan,YAO Fu-mei. The Contradictive Effects of Lipoprotein Lipase in Insulin Resistance and Atherogenesis[J]. Medical Recapitulate, 2006, 12(23): 1431-1433 |
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| Authors: | GE Guang-yan YAO Fu-mei |
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| Affiliation: | 1. Departrasnt of Endocrinoloy , The Second Hospital of Dalian, Dalian 116011, China ; 2. Department of Cardiovascular Diseases, The Second Hospital of Dalian , Dalian 116011, China |
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| Abstract: | Lipoprotein lipase (LPL) is the rate-limiting enzyme in metabolism of triglyceride.Its changes in activity and content can affect its stearolysis function and the lipid metabolism and distribution in whole body,which then resulted in blood fat disorder,hypertriglyceridemia and low level of HDL.These are all the basis of insulin resistance and atherogenesis.Meanwhile,LPL has contradictive effect in the genesis of thses two pathological process. |
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| Keywords: | Lipoprotein lipase Insulin resistance Atherogenesis |
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