Skp2在恶性肿瘤中的作用机制和研究进展

 Skp2（S-phase kinase associated protein）是SCFSkp2（Cul1-Rbx1-Skp1-F boxSkp2）泛素连接酶E3复合体的底物识别亚单位。Skp2参与了多种细胞功能的调节，如细胞周期调控、细胞增生和分化、细胞凋亡等。目前许多研究表明Skp2与肿瘤的发生和预后密切相关。随着对Skp2在肿瘤中的深入研究，Skp2有望成为恶性肿瘤治疗的新靶点和预后评价指标

Function mechanism and research development of Skp2 in malignant tumors

Skp2 (S-phase kinase associated protein) is substrate recognition subunit of SCFSkp2 (Cul1-Rbx1-Skp1-F boxSkp2)complex,a kind of ubiquitin ligases (E3s). Skp2 involves in regulating many functions of cell,such as cell cycle progressing,cell proliferation and differentiation,as well as apoptosis.At present many studies indicated that Skp2 is closely related to tumorigenesis and prognosis.With deeper study of Skp2 in tumor, Skp2 has the potential to be a promising drug target and biomarker of prognosis in human cancer.