| 凋亡抑制蛋白livin在膀胱移行细胞癌中表达及临床意义 |
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| 引用本文： | 祝兴旺,张明明,宋永胜. 凋亡抑制蛋白livin在膀胱移行细胞癌中表达及临床意义[J]. 实用诊断与治疗杂志, 2009, 23(2) |
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| 作者姓名： | 祝兴旺 张明明 宋永胜 |
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| 作者单位： | 1. 中国医科大学附属盛京医院泌尿外科,沈阳市,110004
2. 中国医科大学附属盛京医院病理科,沈阳市,110004 |
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| 摘 要： | 目的:探讨凋亡抑制蛋白livin在膀胱移行细胞癌中的表达及其临床意义。方法:应用SP免疫组织化学方法检测55例膀胱移行细胞癌及10例正常膀胱黏膜组织石蜡切片中livin表达的情况,结合临床资料分析其在膀胱移行细胞癌组织和正常膀胱黏膜中的表达及其与膀胱移行细胞癌临床病理分期、组织学分级和患者复发转移情况的关系。结果:livin在膀胱移行细胞癌标本中的表达阳性率为76.4%(42/55),而正常对照组中无1例呈阳性表达(P<0.01);livin的表达与膀胱移行细胞癌的初发和复发显著相关(P<0.05),但与组织学分级、临床病理分期、转移与否、肿瘤数目无关。结论:livin蛋白在膀胱移行细胞癌组织中表达明显上调,并与膀胱移行细胞癌的复发密切相关,livin蛋白可能通过抑制细胞凋亡,对膀胱移行细胞癌的发生发展起着重要作用,可作为膀胱移行细胞癌早期诊断和评判术后高复发风险的一项重要指标。
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| 关 键 词： | 膀胱移行细胞癌 livin 复发 |
Expression of livin in transitional cell carcinoma of bladder and its clinical significance |
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| ZHU Xingwang,ZHANG Mingming,SONG Yongsheng. Expression of livin in transitional cell carcinoma of bladder and its clinical significance[J]. Journal of Practical Diagnosis and Therapy, 2009, 23(2) |
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| Authors: | ZHU Xingwang ZHANG Mingming SONG Yongsheng |
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| Abstract: | Objective To investigate the expression of livin in bladder transitional cell carcinoma and its clinical significance.Methods The expression of livin was detected with streptavidin-peroxidase immunohistochemical method in the paraffin embedded sections of 55 bladder transitional cell carcinoma patients,and its relationship with pathological stages,histological grades,recurrence,metastasis was discussed.Normal bladder tissues from 10 health people were used as control group.Results The positive rate of the e... |
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| Keywords: | Bladder transitional cell carcinoma livin recurrence |
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