犬椎间隙感染治疗的实验研究

目的探讨椎间隙感染前路病灶清除一期植骨内固定的可行性、安全性及疗效和病理转归。方法犬腰椎间隙内注射金黄色葡萄球菌建立椎间隙感染模型。监测肛温、ESR、CRP；术后2周摄腰椎正侧位X线片和MRI，证实椎间隙感染模型成功建立。32只建模成功的犬随机均分为4组。A组：抗生素治疗；B组：抗生素治疗＋前路病灶清除；C组：抗生素治疗＋前路病灶清除＋椎间植骨；D组：抗生素治疗＋前路病灶清除＋前路椎间植骨＋钢板内固定。治疗后3d及1、2、3周测肛温、ESR、CRP；12周摄X线片后处死，取椎间隙组织病理学检查和培养。结果A组：治疗3周后肛温、ESR及CRP下降缓慢，12周内死亡3只，存活5只未发现椎体间融合。B、C、D3组与A组比较：3周后肛温、ESR、CRP均下降迅速，差异有显著性（P〈0．05）。观察12周感染无复发，但B、C组出现脊柱后凸畸形各1只。12周后D组椎体间融合6只，与A、B、C组相比融合率升高（P〈0．05），无脊柱畸形发生和感染复发。结论前路手术可彻底清除犬椎间隙感染病灶，一期植骨内固定无感染复发，融合率高，病理转归佳。

The experimental study of anterior autografting and internal fixation in treatment of canine pyogenic discitis

Objective To study the feasibility,security,the result of the treatment and pathology of one-stage anterior interbody autografting and internal fixation in pyogenic discitis.Methods Staphylococcus aureus was injected into canine intervertebral space.Pyogenic discitis model were successfully established that were testified by the check-ups of temperature,ESR,CRP,X-ray and MRI.As soon as pyogenic discitis model were successfully established,32 models were divided into four groups by random,group A:antibiotic ...