Extracorporeal membrane oxygenator compatible with centrifugal blood pumps |
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Authors: | Motomura Tadashi Maeda Tomohiro Kawahito Shinji Matsui Takahiro Ichikawa Seiji Ishitoya Hiroshi Kawamura Masaki Nishimura Ikuya Shinohara Toshiyuki Oestmann Daniel Glueck Julia Kawaguchi Yoichiro Sato Koshiro Nosé Yukihiko |
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Institution: | Michael E DeBakey Department of Surgery, Artificial Organ Research Laboratory, Baylor College of Medicine, Houston, Texas 77030, USA. motomura@bcm.tmc.edu |
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Abstract: | Coil-type silicone membrane oxygenators can only be used with roller blood pumps due to the resistance from the high blood flow. Therefore, during extracorporeal membrane oxygenation (ECMO) treatment, the combination of a roller pump and an oxygenator with a high blood flow resistance will induce severe hemolysis, which is a serious problem. A silicone rubber, hollow fiber membrane oxygenator that has a low blood flow resistance was developed and evaluated with centrifugal pumps. During in vitro tests, sufficient gas transfer was demonstrated with a blood flow less than 3 L/min. Blood flow resistance was 18 mm Hg at 1 L/min blood flow. This oxygenator module was combined with the Gyro C1E3 (Kyocera, Japan), and veno-arterial ECMO was established on a Dexter strain calf. An ex vivo experiment was performed for 3 days with stable gas performance and low blood flow resistance. The combination of this oxygenator and centrifugal pump may be advantageous to enhance biocompatibility and have less blood trauma characteristics. |
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Keywords: | Blood compatibility Centrifugal pumps Extracorporeal membrane oxygenation Hemolysis Silicone hollow fiber |
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