| 苦参乙醇提取物体外抗贾第虫药物作用的观察 |
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| 引用本文： | 吴玲清 卢思奇. 苦参乙醇提取物体外抗贾第虫药物作用的观察[J]. 首都医科大学学报, 1994, 15(4): 261-264 |
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| 作者姓名： | 吴玲清 卢思奇 |
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| 作者单位： | 北京联合大学中医药学院寄生虫学教研室，首都医学院寄生虫学教研室，北京医科大学药学院植化室 |
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| 摘 要： | 对苦参乙醇提取物体外抗贾第虫药物作用做了观察。实验结果表明，将此药物与贾第虫滋养体共同培养５ｈ后，导致９９％虫体致死的浓度为５ｇ／Ｌ，随着药物浓度的降低，致死率相应减少；该药的半数致死浓度为１．５ｇ／Ｌ，在此浓度的最短作用时间为３ｈ。对照试验结果显示，在相同时间作用下，阿苯哒唑导致９３．８％虫体致死的浓度为０．２ｇ／Ｌ。
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| 关 键 词： | 贾第虫；苦参乙醇提取物；致死率；半数致死浓度 |
| 收稿时间： | 1993-08-26 |
In Vitro Effect of Ethanol Extract of Sophora Flavescens Ait on Giardia Lamblia |
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| Wu Lingqing. In Vitro Effect of Ethanol Extract of Sophora Flavescens Ait on Giardia Lamblia[J]. Journal of Capital Medical University, 1994, 15(4): 261-264 |
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| Authors: | Wu Lingqing |
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| Affiliation: | 1. Department of Parasitology, College of Chinese Traditonal Medicine, Beijing Union University;2. Department of Parasitology, Capital Institute of Medicine;3. Department of Plant Chemistry,Pharmocology College, Beijing Medical University |
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| Abstract: | Ethanol extract of the Sophora flavecens Ait was evaluated in vitro for antigiardia effect.The lethal concentration to 99% of the organism was 5g/L on the 5h after cultivated with the trophozoites of Giardia lamblia. The lethality rates were decreased with the decline of the drug concentrations when cultivated with the parasites at the same period. The half lethal concentration was 1.5g/L and the shortest time at this concentration was 3h. The control test showed that 93. 8% Giardia trophozites was killed by albendazole when it' s concentration was at 0.2g/L. The present study may provide an experimental datum for the treatment of giardiasis. |
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| Keywords: | Giardia lamblia ethanl extract of Sophora flavescens Ait lethality rate half lethal concentration |
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