葛根素注射液对急性血淤模型大鼠血液流变学及血小板聚集的影响

目的:观察葛根素注射液对急性血淤模型大鼠血小板聚集的影响。方法:给大鼠注射大剂量盐酸肾上腺素和施以冰水浸 泡,制作急性血淤模型大鼠;采用全自动血流变学仪测定不同切变率的全血粘度、血浆粘度、血液屈服应力和红细胞聚集指数等指 标;以比浊法测定各组的血小板最大聚集率。结果:急性血淤模型大鼠的血液流变性呈异常改变,血小板聚集明显增高,葛根素注 射液对异常改变的血流变学和血小板聚集均有明显的改善作用。结论:葛根素注射液可明显改善急性血淤模型大鼠的血液流变学 作用和抑制异常增高的血小板聚集功能,且呈现一定的量效关系。

Effect of puerarin injection on platelet aggregation in acute blood-stasis model rats

OBJECTIVE To observe the effect of puerarin injection on platelet aggregation in acut e blood-stasis model rats. METHODS The acute blood-stasis model rats were made by soaked ice water afer injected a drenaline hydrochloride in a major dose.The viscosities of whole blood and plasm a,blood yield stress and erythrocyte aggregation in the acute blood-stasis mode l rats were measured with Auto-Viscometer,and the maximum rate of platelet aggr egation in all groups were measured by turbidimetry. RESULTS Puerarin injection had amelioration effects on hemorheology and platelet aggreg ation in the acute blood-stasis model rats. CONCLUSION Puerarin injection can ameliorate the hemorheology and platelet aggregation whi ch were abnormal augmentation, and these had a dose-response relationship.