旋转磁场对去卵巢大鼠骨钙含量及其相关因子的影响

目的 研究旋转磁场对去卵巢大鼠骨钙含量，以及骨碱性磷酸酶(BAP)、尿脱氧吡啶交联(DPD)的影响，并观察旋转磁场对雄性大鼠是否有同样的结果。探索治疗骨质疏松的中药是否与磁场有协同作用。方法 磁场处理实验组大鼠每天处理2h共15次后，检测各组大鼠骨钙含量、BAP、DPD，DPD，并与对照组进行比较。结果 无论雄鼠还是去卵巢的雌鼠，凡经磁场处理后，磁场组的骨钙含量和血清BAP含量明显增加，同时DPD下降，服用中药组的实验结果对上述检测项目没有显著影响。结论 旋转磁场能较短时间内有效的促进BAP的升高和DPD的下降，导致去卵巢大鼠股骨的骨钙含量增加，不但再次验证了磁场能够在短时间内有效的提高去卵巢大鼠的骨密度，而且还证明旋转磁场对雄性大鼠也有同样的作用。

Effects of rotary magnetic field on bone calcium content and related factor in rats with ovariotomy

Objective To observe the effects of rotary magnetic to bone mineral content(BMC), bone specific alkaline phosphatase (BAP) and deoxypyridinoline crosslinks (DPD), and to explore if there is synergistic action between the rotary magnetic field and the Chinese Medicine. Methods Experimental rats were exposed to the magnetic field 2 hours a day for 15 days then measured BMC, BAP and DPD then compared with that of the control rats. Results After rotary magnetic treatment, both female and male rats demonstrated a significant increase in BMC and BAP, and a simultaneous decrease in DPD content. Addition of Chinese medicine did not cause any significant difference of these parameters. Conclusion In rats with ovariotomy, rotary magnetic field can increase BAP and decrease DPD in a short time,and increase bone mineral content. These effects were similar in both female and male rats.