| 2-(取代苯氧基)-5-羟基嘧啶类化合物的制备方法研究 |
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| 引用本文： | 魏海洋,刘娜,周有骏,吕加国,朱驹.2-(取代苯氧基)-5-羟基嘧啶类化合物的制备方法研究[J].药学实践杂志,2013,31(6):446-447,469. |
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| 作者姓名： | 魏海洋 刘娜 周有骏 吕加国 朱驹 |
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| 作者单位： | [1]第二军医大学药学院药物化学教研室,上海200433 [2]上海信旗医药科技有限公司,上海200232 |
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| 基金项目： | 国家自然科学基金（20972187）. |
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| 摘 要： | 目的探索2-取代苯氧基-5-苯甲氧基嘧啶、2-取代苯氧基．5-羟基嘧啶类化合物的制备方法。方法以2．氯-5-羟基嘧啶为起始原料，经溴苄羟基保护、威廉森醚合成法、脱苄基保护等多步反应制得目标化合物。结果采用该合成路线制得13个未见文献报道的取代苯氧基嘧啶类化合物。结论本研究提出了一条操作简便、条件温和的全新苯氧基嘧啶类化合物合成方法。
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| 关 键 词： | 2-取代苯氧基-5-苯甲氧基嘧啶 2-取代苯氧基-5-羟基嘧啶 合成 |
| 收稿时间： | 2012/10/24 0:00:00 |
| 修稿时间： | 2013/4/25 0:00:00 |
Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds |
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| WEI Hai-yang,LIU N,ZHOU You-jun,LV Jia-guo and ZHU Ju.Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds[J].The Journal of Pharmaceutical Practice,2013,31(6):446-447,469. |
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| Authors: | WEI Hai-yang LIU N ZHOU You-jun LV Jia-guo and ZHU Ju |
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| Institution: | 1. Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University,Shanghai 200433, China; 2. Shanghai Sinch Pharmaceuticals Tech. Co. , Ltd,Shanghai 200232, China) |
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| Abstract: | Objective To prepare 2-substitudephenoxy-5 - benzyloxypyrimidines and 2 - substitudephenoxy-5-hydroxypyrimi- dines which had not been reported. Methods The target compounds were prepared from 2-ehlorine-5-hydroxypyrimidine through hydroxy protection,Williamsom reaction and reduction of benzyl group. Results The synthetic process provided a simple, easy diposal procedure and high overall yield. Fourteen new phenoxy pyrimidines compounds were prepared. Conclusions It was a new synthetic method which was easy to operate with moderate reaction conditions. |
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| Keywords: | 2-substitudephenoxy-5-benzyloxypyrimidines 2-substitudephenoxy-5-hydroxypyrimidines synthesis |
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