退烧颗粒抗炎镇痛作用研究

目的研究退烧颗粒镇痛抗炎的药理活性，为临床用药提供指导。方法采用醋酸扭体法和热板法实验研究退烧颗粒的镇痛作用；采用二甲苯致小鼠耳肿胀法、鸡蛋清致大鼠足肿胀法考察退烧颗粒的抗炎作用。结果与模型组及对照组相比，退烧颗粒能够显著延长小鼠的疼痛潜伏期，明显提高小鼠痛阈值，减少扭体次数；抗炎作用研究表明，退烧颗粒对二甲苯致小鼠耳肿胀和蛋清致大鼠足肿胀有显著抑制作用。结论退烧颗粒具有显著抗炎、镇痛作用，对感冒引起的发炎、疼痛等症状具有良好治疗作用。

The anti-inflammatory and analgesic effects of Tuishao granule

Objective To study the anti -inflammatory and analgesic effects of Tuishao granule, and provide the basis for clinical studies of the drug. Methods The analgesic effects of Tuishao granule were evaluated by the writhing reaction of mice induced by glacial acetic acid and hot plate, while the anti-inflammatory effects were analyzed by using the mouse＇s ear swelling with xylene and the rats paw swelling with egg white. Result Compared with the model group and the control group, latent time was lengthened signifi- cantly and the pain threshold was increased, the frequency of writhing was reduced in mice by Tuishao granule, which showed that the paw swelling percentage of rats and ear swelling of mice were inhibited by Tuishao granule. Conclusion Tuishao granule had signifi- cant effects on anti - inflammatory and analgesic, which indicatedthat it had favorable effect on the treatment of inflammation and anal- gesic by anemopyretic cold.