| 牛蒡子汤对SD大鼠血液流变性的影响 |
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| 引用本文： | 汤正蓉,黄晓青,褚书弟,梁世瓢,张晓玲. 牛蒡子汤对SD大鼠血液流变性的影响[J]. 中国微循环, 2001, 5(1): 65-67 |
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| 作者姓名： | 汤正蓉 黄晓青 褚书弟 梁世瓢 张晓玲 |
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| 作者单位： | 1. 上海市中医药大学附属岳阳医院伤骨科
2. 华东师范大学生物系 |
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| 摘 要： | 目的 探析牛蒡子汤治疗颈椎病的作用机理。方法 分组灌胃牛蒡子汤基础方和加减方，比较了受试大鼠的血液流变学和血清中MDA、SOD以及NO的含量。结果 牛蒡子汤基础方和加减方可使大鼠的BEVH、RBVL、PV、PtA和ESP均有不同程度的下降，可改善红细胞的变形能力和聚集性，减缓血小板的聚集性，有利于血流和微循环灌注。可有效降低实验动物血清MDA的水平，提高SOD的活力，可调控一氧化氮。结论 牛蒡子汤对颈椎病祛风通络、活血化瘀的药理与血液流变性改善以及提高清除自由基能力、对抗退行性病变有关。
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| 关 键 词： | 牛蒡子汤 血液流变学 MDA SOD NO 中药 药理 |
| 文章编号： | 1007－8568(2001)01－0065－03 |
| 修稿时间： | 2000-10-14 |
Effect of Arctium LappaSoup on Hemorrheology in SD Rats |
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| TANG Zheng-rong,HUANG Xiao-qing,CHU Shu-di,et al.. Effect of Arctium LappaSoup on Hemorrheology in SD Rats[J]. Journal of Chinese Microcirculation, 2001, 5(1): 65-67 |
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| Authors: | TANG Zheng-rong HUANG Xiao-qing CHU Shu-di et al. |
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| Affiliation: | TANG Zheng-rong,HUANG Xiao-qing,CHU Shu-di,et al. Department of Traumatology,Yue Yang Hospital Attached to Shanghai Chinese Medicine University,Shanghai 200041, Department of Biology,East China Normal University,Shanghai 200062,China |
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| Abstract: | Objectve To investigate the mechanism of Arctium lappa soup on the treatment of cervical spondylosis. Methods Effect of Arctium lappa soupa (basic and plus or minus) on hemorrheology and MDA or SOD in serum as well as nitric oxide in plasma of SD rat groups were compared by filling it. Results The experiments showed that BRVH、 BRVL、 PV、 PtA and ESR in test groups compared with the control were significantly decreased; and that the shape change ability,the collect character of erythrocyte and platelet aggregation rate were obviously improved, it is helpful to blood flow and microcirculation perfusion. The test revealed MDA levels and SOD vigor in serum of SD rats were decreased and increased, respectively, Nitric oxide was regulated by Arctium lappa soup. Conclusion The experiments suggested that pharmacology of Chinese traditional medicine is related to improved hemorrheology, free radicals clearance and anti_retrograde pathological changes in the treatment of cervical spondylosis. |
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| Keywords: | Arctium lappa soup Hemorrheology MDA SOD NO |
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