寻常型银屑病患者尿中微量蛋白含量的临床研究

用酶联免疫分析法检测46例寻常型银屑病患者尿白蛋白和IgG含量,并分析了它们与病程、疾病分期、皮损严重程度以及血清白蛋白水平之间的关系.结果表明,患者组的尿白蛋白和IgG含量显着高于对照组(P<0.01),进行期时显着高于静止期(P<0.05),皮疹消退时尿白蛋白和IgG含量显着低于进行期(PP<0.05),而皮疹复发时又显着增高(P<0.05),提示尿白蛋白和IgG检测可早期发现银屑病的肾脏改变并可作为判断病情和估计疗效的参考指标.尿白蛋白和血清白蛋白之间的显着负相关关系(r=-0.8762,P<0.01)可能解释银屑病血清白蛋白低下的原因.

A Clinical Study on Microalbuminuria of Psoriasis Vulgaris

Urine albumin (Alb) and IgG content were detected in 46 patients with psoriasis vulgaris by ELISA method. The relationship between urine Alb and IgG content and duration of disease, different stages of disease, PASI and levels of serum albumin were also analyzed. The results showed that urine Alb and IgG content of patients were significantly higher than those of controls (P<0 01). They were significantly higher in active stage than in steady stage (P<0 05). And they decreased significantly when lesions disappeared (P<0 05) but increased significantly again when lesions relapsed (P<0 05). It is suggested that the detection of urine Alb and IgG can help to find nephropathy of psoriasis earlier and it can be taken as an index for evaluating status of the disease and therapeutic effects. The negative linear correlation between urine Alb content and serum albumin can explain why serum albumin decreases in psoriasis.