Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug |
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Authors: | Zhang Shaoling Kawakami Kohsaku Yamamoto Marina Masaoka Yoshie Kataoka Makoto Yamashita Shinji Sakuma Shinji |
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Institution: | Biomaterials Center, National Institute for Materials Science, Tsukuba 305-0044, Japan. |
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Abstract: | Development of oral dosage forms containing poorly water-soluble drugs is a major challenge in the pharmaceutical industry. This paper describes the use of coaxial electrospray deposition as a promising formulation technology for oral delivery of poorly water-soluble drugs. The technology produced core-shell particles composed of griseofulvin and poly(methacrylic acid-co-methyl methacrylate) (Eudragit L-100), with a diameter of around 1 μm. The drug phase was in an amorphous state when the griseofulvin core was coated with the Eudragit L-100 shell. The in vitro dissolution and in vivo oral absorption studies revealed that the core-shell formulation significantly improved dissolution and absorption behaviors, presumably because of a reduction in particle size, improvement in dispersity, and amorphization. Results demonstrated that coaxial electrospray deposition possesses great potential as novel formulation technology for enhancing oral absorption of poorly water-soluble drugs. |
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