动脉自旋标记序列对前列腺癌血流灌注无创定量测量的可行性研究

目的：探讨基于流动敏感交替反转恢复标记技术（FAIR）结合单次激发快速自旋回波（SSFSE）成像技术的动脉自旋标记（ASL）序列无创定量测量前列腺血流灌注（PBF）的可行性。方法：15例经临床活检确诊的前列腺癌患者纳入本组研究，每例患者同时采集4个不同反转时间（1000、1200，1400和1600ms）下的ASL数据，以获得最优的标记血流到前列腺时间来估算其PBF。结果：前列腺正常组织区域测得的PBF为（52．04±8．69）ml／min／100g，前列腺癌区测得的PBF为（79．28±28．89）ml／min／100g，两者差异有统计学意义（P〈0．01，最优TI），表明前列腺癌区有更大的血流灌注。结论：初步结果表明基于流动敏感交替反转恢复标记技术结合单次激发快速自旋回波成像技术的动脉自旋标记序列（FAIR-SSFSE—ASL）可以无创、定量测量前列腺血流灌注，可探测到由于前列腺癌而引起的血流灌注改变。

Feasibility of non-invasive quantitative ts of prostate blood flow in prostate cancer using an arterial spin labeling sequence

Objective：The purpose of this study was to demonstrate the feasibility of arterial spin labeling （ASL） se- quence for non-invasive quantitative measurements of prostate blood flow （PBF） in prostate cancer. Methods.. Whether the measurement of PBF by FAIR-SSFSE-ASL carl refect prostate blood flow changes induced by prostate cancer in 15 prostate cancer subjects （confirmed by biopsy） with a mean age of 70.9 years was evaluated. Moreover,different levels of inversion times （TI： 1000,1200,1400 and 1600ms） were utilized to obtain the optimal time of the inflow of labeled blood into pros- tate on the estimation of PBF. Results：The estimated PBF was （52.04~8.69）ml/min/100g in the prostate normal region, and significant increase of PBF in the prostate cancer region was （79.28~28.89）ml/min/100g （P〈0.01 at optimal TI）, reflecting an increase of blood flow in the prostate cancer region. Conclusion.. In summary,we have demonstrated that non-in- vasive quantitative measurement prostate blood flow can be obtained using an FAIR-SSFSE-ASL sequence. The measure- ment can reflect the expected prostate perfusion changes induced by prostate cancer.